ID A0A3Q4HIK4_NEOBR Unreviewed; 422 AA.
AC A0A3Q4HIK4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Bone morphogenetic protein 5-like {ECO:0000313|Ensembl:ENSNBRP00000016882.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000016882.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000016882.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q4HIK4; -.
DR Ensembl; ENSNBRT00000017339.1; ENSNBRP00000016882.1; ENSNBRG00000012531.1.
DR GeneTree; ENSGT00940000158644; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000012531; Expressed in heart and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19395; TGF_beta_BMP5; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF139; BONE MORPHOGENETIC PROTEIN 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..422
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018773864"
FT DOMAIN 302..422
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 285..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 47464 MW; 5A4B7A85EAB600EE CRC64;
MTALTPLNRA VLGLAWSCLS FLSCVHCVLS DNHVHSSFIY RRLRNHERRE IQREILSILG
LPHRPRPFSP GKQASSAPLF MLDLYNAMAV DEEEGVQESA GKSFSAKAQG PALTTAQDTN
FLNDADMVMS FVNLVEKDKD FSHQRRHYKE FRFDLTQIPD GEAVTAAEFR IYKDRSHARY
DNITLKVTIY QVIKEDAETF LLDSKKVQAS DGGWLVFDIT ATSNHWVMNP QQNLGLQLCV
ETVDGRSINI KSAGIIGRNG PQSKQPFLVA FFKASGVLLR SVRAAGGKKK NHNRNKLNNQ
QQSSKAPKTG DYNTSEQKQA CKKHELYVSF RDLGWQDWII APEGYAAFYC DGECSFPLNA
HMNATNHAIV QTLVHLMFPD NVPKPCCAPT KLNAISVLYF DDSSNVILKK YRNMVVRSCG
CH
//
