ID A0A3Q4HIM0_NEOBR Unreviewed; 3918 AA.
AC A0A3Q4HIM0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dynein heavy chain 12, axonemal-like {ECO:0000313|Ensembl:ENSNBRP00000020398.1};
GN Name=DNAH12 {ECO:0000313|Ensembl:ENSNBRP00000020398.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000020398.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000020398.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 32507.ENSNBRP00000020398; -.
DR Ensembl; ENSNBRT00000020948.1; ENSNBRP00000020398.1; ENSNBRG00000015436.1.
DR GeneTree; ENSGT00940000154280; -.
DR OMA; CIEWQRY; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000015436; Expressed in testis.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 1226..1365
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1507..1646
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1861..2009
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 703..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 862..889
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2714..2769
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3918 AA; 447733 MW; 51FF4DD72A9F34C0 CRC64;
MSDFPVLPPI KGAQQLGEIE QIIAKKEEIA EKVAKAAKVS KKLLRHKRSK MEVKQRQKIL
YVFSSMNYNF LKQCVERREC PVIQQQWLDS IVDRVPAKLR GNPESEKLLQ ELCKEVSDNF
NSVIVKYTVG TVLKNPQADG LNSEKQSATQ PKIPSFSRPW HDSFIRSQKM IKANLHILNP
VMQTLLDLGN TTFSSLVLIE ASGPVDSKSL QNKMAVECKR TEDRIMNTWF PKVIHLLTNQ
KTLKGVKEEK IDSFYNCAST LISNQLKSLL HGSVEEFVGV FDPSNHHRLP IFRMALTFDD
EKMEIYPALQ DLEAAVLEIL SKVQTVQSWL AQNTSLFVDA KVTDEIHAWA QATVKSAVRR
NLEEPEKYFQ NYVDSYDWLV DGTAQAKVEM FMEEEHSFDE YTKQVEEFRA LSKEIMSLPS
KARFTMVHLD CEELKQGLAN KAKAYAEVLL KKLVSRHHEQ NLEICSEFEN IRMRASKVPE
NTEEMAQMLD FIHEAKSKGL AELNEKIKEA CCRLIYLLEV HVIEAEDMEL NSTVFLWPQN
ILHTFELSDE LMEKAKKKGE DELVAKREKL MVQLEKLGRR TDEFSFLSEL EMMQQYVADV
RIVQKLLHEA EEAITLINKE EAFYKWDLTC FPEVEIIKEN IEPYQKLFGF VLNWQRTESR
WMDGSFQDLN GETMEVKVDE FYREIFKMLK FFQQKKIKAA QEMERISEKR RRHPTEDDVT
KEESPTVSLC SAVMEQIKNF KKHIPLVSIL CNPGLRSRHW TQMSQIVRYE ITPNSGTTLR
KVLKQNLAPY LEDFESISAA ASKEFSLEKA MKTMVGIWDS VSFHHQPYRE TGVSILTTLD
DIQTMLDDQI VKTQTMRGSP FIKPFENEIK QWEERLLRIQ ETIDEWLKVQ AQWLYLEPIF
SSKDIMQQIP EEGRLFQTVD RNYKEVMRHC VKNPKILPAT SLPGLLEKLQ DSNTLLDSIM
KGLNAYLEKK RLFFPRFFFL SNDEMLEILS ETKDPQRVQP HLKKCFEGIS KLDFLPNLDI
QAMYSSEGER VQLIQHISTS EAKGAVEKWL IQVEDVMLRS VRDVIARSRV AYAETPRSQW
VTEWPGQVVL CTSQIFWTLE VHEAIRAHPN GLKNYYQKLQ SQLNDIVELV RGKLAKQTRI
TLGALVTIDV HARDVVMELI EKGVSQEADF QWLAQLRYYW SSDNVRVRII NCDVKYAYEY
LGNSPRLVIT PLTDRCYRTL IGAFYMNLGG APEGPAGTGK TETTKDLAKA LAVQCVVFNC
SDGLDYLAMG KFFKGLASSG AWACFDEFNR IELEVLSVVA QQVLCIQRAI EQKLEYFDFE
GTMLKLNPNC FVSITMNPGY AGRSELPDNL KVLFRTVAMM VPNYALIAEI SLYSYGFLNA
KPLSVKIVMT YRLCSEQLSS QFHYDYGMRA VKAVLVAAGN LKLKYPKENE DILLLRSIKD
VNEPKFLSHD IPLFNGITSD LFPGISLPEA DYQLFLEAAK ECCKNHNVQP TDVFIQKMIQ
TYEMMIVRHG FMLVGEPFAG KTKVLHVLAD TLTLMNVRGH GQEEKVIFMT LNPKSITMGQ
LFGQFDLVSH EWTDGIVANT FREFASADTP DRKWVVFDGP IDTLWIESMN TVLDDNKKLC
LMSGEIIQMS NQMSLIFEAM DLSQASPATV SRCGMIYMEP SQLGWKPLVL SWMNTLLDDL
QTPDNRSLLL ELFHWLLPPA LTMLRKHCRE VVSRSNSNIA VSLCRLFEML LTKPVKTGQT
DKNIRCWIMA AFAFSLVWSV GGSCDADSRE KFSSFFRLIV AGQKNEHPIP ETVGKWECPF
EEKGLVYDYF YEFKGKGKWF HWNESIKNIN LGDKTTKVQE IIVPTIDTVR YNYLMDLCIN
YEVPSLFVGP TGTGKSVYVK EKLMNNLDKD QYLPFFINFS ARTSSNQTQN IIMSRLDKRR
KGVFGPPMGK KCIIFVDDMN MPALEQFGAQ PPVELLRQYI DHGNWYDLKD TSKITLVDLQ
IISAMGPPGG GRNAVTSRFL RHFNIFSINP FSDDTMVHIF SNIVSFYLKN NQFPPEYFTV
GNQIVTATME VYKKAMENLL PTPTKSHYTF NLRDFSRVIQ GCLLIKKGSL ESKRTMIRLF
VHEVFRVYYD RLVDDDDRVW LYTLMSSIVK DHFKESFHQV FDHLKQGSKL VEEDMRNLLF
GDYMNPDLED DERLYAEVPS VENFAVVVKS CLEEYNQMHK NRMNLVIFRY VLEHLSRVSR
VLKQPGGNAL LVGVGGSGRQ SITRLATFMA HMTMFQPEIS KSYGMTEWRD DLKMLLKNAG
VKGQKTVFLI TDAQIKDEAF LEDVDSVLNT GEVPNLFAID EKQEIIEAVR PIAQAGNKNL
ELSPLTLFAF FVARCKENLH IVVAFSPIGD AFRNRLRQFP ALINCCTIDW YQPWPEEALE
RVANSFLESL QMNENERQEV IPICKTFHTS AKELSQRFLS ELGRHNYVTP TSYLELIAAF
RQLLTQKRDT VMKAKQRYTN GLDKLAFAES QVGEMKKELV DLQPKLEQAK IENTKMMKVI
EVESVEVEAK SKVVRVDEEA ATIKANEAQA LKDECESDLA EAIPALEAAL SALDTLKPSD
VTIVKSMKNP PSGVKLVMAA VCVMKEIKPD KIADPAGTGK KVFDFWGPSK KLLGDMNFLR
DLRIYDKDNI PVHVMQKIRS EYMTNPDFNP SIVAKASSAA EGLCKWIQAM EVYDRVAKVV
APKKANLGVA QESLAATMAL LDQKRAELKE VEDRLAALQK TFQEKTEEKA QLEFQVDLCA
RKLERAEKLI GGLGGEKTRW SKAADDLQNT YDNLTGDVLI SAGVIAYLGA FTAGFRQECT
KLWTKLCKSK NIPSSNDFSL SKTLGDPIKI RAWNIAGLPS DTFSIDNGVI VSNSRRWPLM
IDPQGQANKW VKNSEKDNSL SVIKLTDGDY MRTLENCIQF GTPLLLENVG EELDPSLEPL
LLKQTFKQGG VDCIRLGESV IEYSNDFRFY ITTKLRNPHY LPELATKVSL LNFMITPEGL
EDQLLGIVVA KERPELEEER NALILQSAEN KRQLKETEDK ILETLQSSEG NILEDESAIQ
ILDSAKIMSN TITKKQQIAE KTEIKIAESR EGYRAIAKHS SILFFSITDL TNIDPMYQYS
LSWFVNLYIN SIQDSNKSKI LERRLQFLID HFTYNLYCNI CRSLFEKDKL LFSFLLCCKL
LLAKGEIKHT DFMFLLTGGV GLQNTTANPD PTWLQDKSWD EICRASELPG LRGLKEAFIK
NPDDFKTIYD SKDPCTIDLP APWCEKLNDL QKMIIVRCLR PDKILPAVTK YVKRKLGKKF
VQPPPFDLSK SYLDSNSAIP LVFVLSTGAD PMASLLKFAS DKNMGGAKFQ SISLGQGQGP
IASKMISTAM QDGTWVCLQN CHLAVSWMPT LEKICEDFSL ATCHQDFRLW LTSYPSAKFP
VTILQNGVKM TNEPPTGLRL NLLQSYLSDP ISDPNFFSNC PNKELSWEKL LYGLCFFHAL
VQERKKFGPL GWNIPYGFNE SDLRISIRQL QLFVNEYDKV PLEAITYLTG ECNYGGRVTD
DWDRRLLMTI LADFYNKDII ETFRYPFSPS GDYCAPPKSS YQDYILFIKE LPFSQHPEVF
GMHENVDISK DLQQTKLLFD SLILTQGGGS EGGTHSESDN MLYDIANDIL TKLPANFDTE
AALLKFPVLY EESMNTVLVQ EMERYNTLCS LIRISLQNLL KAIKGLVVMD AELEAVAGSL
VVGKVPEKWA KRSYPSLKPL GSYINDFLSR LKFLQVWFNT SKPNVFWLSG FFFTQAFLTG
AMQNYARKYH IPIDLLSFEF EVLPFDEIQT APEDGVYING LFLDGARWDK ESGVLAEQYP
KVLFDSMPII WVKPTQKNSV SQPQKMYICP LYKTSERKGT LSTTGHSTNF VISMTLPTNK
HPQHWIKRGV AMLCQLDD
//
