ID   A0A3Q4HIX7_NEOBR        Unreviewed;       720 AA.
AC   A0A3Q4HIX7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Unconventional myosin-X-like {ECO:0000313|Ensembl:ENSNBRP00000021981.1};
GN   Name=PLEKHH3 {ECO:0000313|Ensembl:ENSNBRP00000021981.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000021981.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000021981.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q4HIX7; -.
DR   STRING; 32507.ENSNBRP00000021981; -.
DR   Ensembl; ENSNBRT00000022566.1; ENSNBRP00000021981.1; ENSNBRG00000016844.1.
DR   GeneTree; ENSGT00940000159764; -.
DR   OMA; QCLMGDF; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000016844; Expressed in liver and 8 other cell types or tissues.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR038185; MyTH4_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR46049; AGAP003327-PA; 1.
DR   PANTHER; PTHR46049:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF00784; MyTH4; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00139; MyTH4; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS51016; MYTH4; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          32..133
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          171..325
FT                   /note="MyTH4"
FT                   /evidence="ECO:0000259|PROSITE:PS51016"
FT   DOMAIN          330..687
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
SQ   SEQUENCE   720 AA;  82354 MW;  2957F59515B9C20F CRC64;
     QPQKWQLWWL CAAFNAYAII WPYFYKSQKY AFCLFKGWLL REVRGNWIKQ RRYWFVLTQD
     SLDYYTGPEK GARRLGTLVL TNLCSVIWPD KQTYKETGYW SITVYGRKHC YRLYTKHFNE
     AVHWACAIQK IIDSKSPVET PTQLLIRDIE ENKFNPEVVE HIYQHNPILK YTQGPLYAPL
     LPFPYDHSGK GYGSVREEAV KLFNCLQQLE SAREPVPIIQ GVLQTCLDLR PLRDEVYCQL
     VKQTSYTPSP NTAAHLRYWQ LLTCMSCTFL PGPIVLKYLR FHLKRIQSQS PESEMDNYAS
     FISEALEKTK CRECVPSWEE IQMLMNRQEM LCTVHYPGPG SCQLYISSHT TANEVVRRMQ
     EKLGLQESKN TFALYEQNAL WEQPVTGGAL VADILTRFEK VTSESKSQWK LCFKLYCLLD
     ADSISVDSIE YLFLFEQCHE MVVRGQLPAC EEDLQALAAL RLQSLMGDFS THAPCPPLDE
     LFPGHMLETR VLVSISAPQD VPPCQVAAQG CPTTQRFHTG LLAGTLWSHT ATAVHKQKVE
     QDMRLRTRLK EEAAAVMTSI LERWKGLAGY SRRDSMAAYL TIARQWSGFG CTLYERNLNP
     SSTGSFSQKL WLGVAATSVS LYKQGESEAL ESFPYGQICS YGVSDSNTFK ITAGDRDLLF
     ETTKLTEIMQ LMNAYFSAIH RQRGKGEDAD ITIADSTEVG FRHLRSAPTP TLLELPSHPV
//