ID A0A3Q4HJZ3_NEOBR Unreviewed; 792 AA.
AC A0A3Q4HJZ3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Leucine-rich repeat-containing protein 8A-like {ECO:0000313|Ensembl:ENSNBRP00000017452.1};
GN Name=LRRC8A {ECO:0000313|Ensembl:ENSNBRP00000017452.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000017452.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000017452.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR RefSeq; XP_006803911.1; XM_006803848.1.
DR AlphaFoldDB; A0A3Q4HJZ3; -.
DR STRING; 32507.ENSNBRP00000017452; -.
DR Ensembl; ENSNBRT00000017922.1; ENSNBRP00000017452.1; ENSNBRG00000013485.1.
DR GeneID; 102796819; -.
DR CTD; 557928; -.
DR GeneTree; ENSGT00940000154043; -.
DR OMA; HNVQEID; -.
DR OrthoDB; 55205at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000013485; Expressed in blood and 7 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF3; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 5.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..322
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
SQ SEQUENCE 792 AA; 92559 MW; 4EF374038804D933 CRC64;
MIPITELRYF VDTQPAYRIL KPWWDVFTDY ISIVMLMISV FGGTLQVTQD KMICLPCKWV
VNETCKRNFN SSITSSVPKG IQYDLDRHQY NYVDAVCYEN TLHWFAKYFP YLVLLHTLIF
LACSNFWFKF PRTSSKLEHF VSILLKCFDS PWTTRALSET VVEESDPKPM KMNGSMDHKE
SVISEDVEAS VPMLQRTKTR FEQGIVDRTE TGVLDKKEGE QAKALFEKVK KFRIHVEEGD
IVYRLYIRQT IIKVIKFILI ICYTGYYVHD IQFSVDCSVN IESLTGYSVY RCAHPLATLF
KILACFYISL VVVYGLICMY TLCWMLRRSL KKYSFESIRE ESSYSDIPDV KNDFAFMLHM
IDQYDPLYSK RFAVFLSEVS ENKLRQLNLN NEWTLDKLRQ RITKNSQEKL ELHLFMLSGI
PDTVFDLMEL EVLKLELIPD VTIPPIIAQL VNLREMWLYH TPAKIEAPAL AFLRENLKSL
HIKFTDIKEI PLWIYSLKNL SELHLTGNLS AENNPYIVID GLRELKRLKV LRLKSNLTKL
PQVVTDVGMH LQKLSINNEG TKLMVLNSLK KMVNLTELEL IRCDLERIPH SIFSLHNLQE
IDLKDNNLKT IEEIISFQHL HRLVCLKLWY NQIAYIPIQI GTLNNLEKLY LNRNKIEKIP
SQLFYCRKLR ILDLSHNNLT YIPTDIGFLQ NLQYLAVTAN RIENLPNELF QCKKLRTLNL
GNNCLQSLPS RFGELTALTQ LELRGNRLEC LPVELGECRQ LKRTGLVVEE DLFNTLPTEV
KEQLWKADKE QA
//
