ID A0A3Q4HKH0_NEOBR Unreviewed; 2822 AA.
AC A0A3Q4HKH0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=IgGFc-binding protein-like {ECO:0000313|Ensembl:ENSNBRP00000023960.1};
GN Name=FCGBP {ECO:0000313|Ensembl:ENSNBRP00000023960.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000023960.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000023960.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 32507.ENSNBRP00000023960; -.
DR Ensembl; ENSNBRT00000024583.1; ENSNBRP00000023960.1; ENSNBRG00000018217.1.
DR GeneTree; ENSGT00950000183155; -.
DR Proteomes; UP000261580; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 6.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR035234; IgGFc-bd_N.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR025615; TILa_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR46160; ALPHA-TECTORIN-RELATED; 1.
DR PANTHER; PTHR46160:SF4; VWFD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08742; C8; 6.
DR Pfam; PF17517; IgGFc_binding; 1.
DR Pfam; PF01826; TIL; 6.
DR Pfam; PF12714; TILa; 6.
DR Pfam; PF00094; VWD; 7.
DR SMART; SM00832; C8; 6.
DR SMART; SM00214; VWC; 5.
DR SMART; SM00215; VWC_out; 6.
DR SMART; SM00216; VWD; 6.
DR SUPFAM; SSF57567; Serine protease inhibitors; 6.
DR PROSITE; PS51233; VWFD; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..2822
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018781548"
FT TRANSMEM 2414..2432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 463..494
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 500..583
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 791..970
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1179..1347
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1582..1764
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1975..2153
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2363..2530
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
SQ SEQUENCE 2822 AA; 309935 MW; CDF3B64BA1FC2FBC CRC64;
MPAFFISENV KSSYSVFFAV FLLSHLLPGP SSAGWAGREF ALSFLQNYLQ HYDTPQYELH
ITAIQANTKV TVQVPPLSFK QEKTLKAGEV VTISLPNGVE MYGSTKSSNT VRIEASADVT
VTSFNYKLYT ADTSVIYPVS EWGTEYFIFT PPGTPYATFK EFSVTNGKEA QEVEIFPQGA
IKFENRVYDQ NSKMVLNLKP YESVQLQSSY ELSGTRVSSK HPVAVFTGHT CTWRFAKCNH
VYEHLLPVSS WGTSFVMPPL SFQKNFDSVY LQASQNTSVT VQNGQRKDDL SLSTGQTIEI
QYHNPDALSI QADHGIQVLL LFNGVEHSWL LYYDPFLTNI ISTDRFCFSY SFEALAGFEN
KALVVAQTSA AATLRWDNTE LPRDVQWKKI EGSEFSWAEI SYNQSPTNNK HTLSSSGSPF
GLYSIGFSQM NGYGSLGQCV QPGKQHTMKD GRPSCVPVKK NPGTCWAMGD PHYRTFDGRH
FNFMGTCTYV ISKTLKVFDV TITVSGSSVL IEADFGLTVR YDWEQRLVVT LCSSYAGKTC
GLCGNFNGNP SDDFTTPSGA QAGGALAFGR SWKVPGLGEA QCRDDCTDGL DNCESSLMKT
WESDLFCGII ALDLFSKCHK IIDPLPYIED CKYDLCMGGG LRHFLCSAVE AYAEACQIAG
VQVQEWRKKA QCPAKCPANS QYELCGSACP DTCSDPNASS KCKRPCVETC TCKAGFVLSG
DKCVPAAQCG CTYEGRHIPP GEAFWADQGC KRWCKCVAGS RQVQCEEKGC RTGEECKVVD
GIRKCQAVSF STCQATGDPH YMTFDKKKFN FQGTCVYQLV ALCSKDPELV PFEILVQNDH
RGSKVVAYTG LVEIKVYSFS IIITKTHKGQ LMVNNELVNL PITLVEGKIS VYKSGWYAVV
TTDFGLKVSF NWDSAVFVTL PSNYMGAVCG LCGNYNGKPE DDLIPKNGKT PVSPADFGTS
WRVAEIPGCV EGCKGVCPDC DINQKVQYEK DDFCGVIKDA KGPFRDCHAK VDPASFFEDC
VYDVCLYKGR KDILCKAITA YTSACQAAGA NVYNWRTVHF CAMQCPTNTH YEICAIACPA
TCQSLTPPKG CQAQCVEGCS CDDGYILSGD ACVPLSECGC VYNNRYYRTG EVFYPNGQCE
EECNCKKGGE VECKKFTCGP NEKCKIENGV QKCHPVGKGV CQAAGDPHYL TFDGKKFDFQ
GTCTYTLSKS CGLEGTHLVD FSVQVENEQW DRVMNRKVVS VTKLVAVEVN GVLSYLPMNL
NDGAILVYQE GNRYVIATNF GLLVTYDLVY QVTVTLPGNY RGKVCGLCGN YNGDRNDDFE
MPNRRLTNNV NEFGKSWKVT IPNVVCENGC EGNSCPECDP ALKAVFSKSA YCGIMTNPNG
PFAVCHSILD PQPYFADCVF DLCASNGDGK VLCDSVAAYA FNCHIVGADV KNWRTPSFCP
MKCPINSHYE VCAEACSASC AGLTEIVQCP SNCTEGCDCD TGFLFNGQTC VKEIECGCYE
NGKTYKPGDV VYEEDCNRKC TCNPGKGLIC EKHSCPQDTK CMVKNGIRAC YNTDPCKDLK
CRAQETCRVD KGKATCIPKY TGTCWAWGDP HYHTFDGYNY DFQGTCKYVI SKTCGELDGL
VPFLITERND NRGNTAVSYV RNVDVFVYDY QITIQKNQVG QVMVDGELLN LPVHLGDGKV
SVLQRGNTAE VVTDFGLVVS YDWNWYLVIK LPSSYYGLVC GLCGNFNANV LDEMLNPAGK
KVSSVIEWGK SWLAPEQDKE HPCWDTCEKN CPTCDNNDVK LYKTEAFCGA LADKTNGVFQ
TCHEKVDPQA FMNNCVYDMC YNKGDKKMLC QALASYSDKC RDEGIIIKNW RTKFGCPMNC
QRNSHYEDCA SPCQPSCPFT EEKQVCSGTC VETCVCDKGY VLSAGVCVPA KTCGCSYQGR
YYKPGQQFWD DEACHRLCEC DMTLGIVACR EASCSAKEQC TVVDGERACR PISYATCSAS
GDPHYRTFDG RRYNFQGTCV YQLAGLCSQQ PGLVPFKVTV QNDHRGSKAV SYTSTVKFSI
YGITLTISRE YPYKVLVSDD LVLLPLNYNN ELMVSLSGWK AVVETAAGIT VTFDWQSTVT
VTLPSTYQGA VCGLCGNYNN KAQDDLTMPN GNTTSDERQL GDSWQVSIVP GCSSVCQGPW
CQACSDSQKK VYEANKYCGI IADKAGPFKD CHSRVDPAPY MEDCVFDVCQ YQGHHGSVCD
AVEVYASACQ SIGVTIYSWR AESFCPMACP ANSHYSLCAT GCPATCASLT PLTSCHRYCS
EGCECDEGYL LSGDTCMPVK DCGCSYDGQY YQKGDVFYSE DKCAEECTCG DNGAVSCQKA
TCRPGEICKL VNGVKGCYPE GEGKCVASGD PHYISFDGRR FDFQGTCVYV LAKVCDDDKD
MFCIFSHFFP KNDFFVSIFF FFFFFFVSIF KVDDELLNLP LSLENGRLKI TQEGRNIVVR
TAFGLTVLYD TVYYVEVIVP STYQGKMCGL CGNYNKNGGD DFILPGGKQA KNVDEFGMAW
TVDLPGYMCG GCGGQCPECE QAKAVLYGKP DSCGIISAPN GPFKACHSVI DPAVYLSDCV
FDVCAVGGNK DTLCNSVQAY ALACQSAGVQ IQQWRSNSFC PASCPPHSHY ELCADTCSGT
CASFVTPFGC FPGCFEGCQC DDGFVFNGVQ CVVLEDCGCM YNGRYLMVGQ ELVENDCKSK
CVCQASGMVK CEKLSCASGE VCDIRDGVRG CHLKQGQCVV SRDGQLSSFD GMSGAIGAQG
AFQVASLCNE SAELWFRVVV DVRVCNKGAA PTVASVYVFF SDTIVVVNSE HVTWVRTFLC
KN
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