ID A0A3Q4HLC4_NEOBR Unreviewed; 225 AA.
AC A0A3Q4HLC4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Retinol-binding protein 4-A-like {ECO:0000313|Ensembl:ENSNBRP00000024290.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000024290.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000024290.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000256|ARBA:ARBA00006889, ECO:0000256|PIRNR:PIRNR036893,
CC ECO:0000256|RuleBase:RU003695}.
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DR RefSeq; XP_006791300.1; XM_006791237.1.
DR AlphaFoldDB; A0A3Q4HLC4; -.
DR STRING; 32507.ENSNBRP00000024290; -.
DR Ensembl; ENSNBRT00000024928.1; ENSNBRP00000024290.1; ENSNBRG00000018579.1.
DR GeneID; 102793456; -.
DR CTD; 5950; -.
DR GeneTree; ENSGT00510000047107; -.
DR OMA; KYWGMAS; -.
DR OrthoDB; 5342507at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000018579; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProt.
DR GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR GO; GO:0034632; F:retinol transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0032526; P:response to retinoic acid; IEA:Ensembl.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR022271; Lipocalin_ApoD.
DR InterPro; IPR022272; Lipocalin_CS.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002449; Retinol-bd/Purpurin.
DR PANTHER; PTHR11873; RETINOL-BINDING PROTEIN 4; 1.
DR PANTHER; PTHR11873:SF2; RETINOL-BINDING PROTEIN 4; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PIRSF; PIRSF036893; Lipocalin_ApoD; 1.
DR PIRSF; PIRSF500204; RBP_purpurin; 1.
DR PRINTS; PR01174; RETINOLBNDNG.
DR SUPFAM; SSF50814; Lipocalins; 1.
DR PROSITE; PS00213; LIPOCALIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR036893-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Retinol-binding {ECO:0000256|ARBA:ARBA00023072};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 63..183
FT /note="Lipocalin/cytosolic fatty-acid binding"
FT /evidence="ECO:0000259|Pfam:PF00061"
FT BINDING 140
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036893-51"
FT DISULFID 46..202
FT /evidence="ECO:0000256|PIRSR:PIRSR036893-50"
FT DISULFID 112..216
FT /evidence="ECO:0000256|PIRSR:PIRSR036893-50"
FT DISULFID 162..171
FT /evidence="ECO:0000256|PIRSR:PIRSR036893-50"
SQ SEQUENCE 225 AA; 25510 MW; 4B3EFF52403A7745 CRC64;
MQYWPAVFKA SPDGKSEDFF GVFVVSRMLR YVVALSLLAL CWAQDCQVAN INVMQNFDKT
RYAGTWYAVG KKDPEGLFLL DNIVAQINIE EDGKMTATAQ GRVIILNNWE MCAHMFATFE
ETADPAKFKM KYWGAASYLQ TGNDDHWVID TDYDNYAVHY SCRLVDADGT CLDGYSFIFS
RHSTGLRPED QPVVLQKKTD LCLLGKYRRV THTGFCESGT SLDPQ
//
