ID A0A3Q4HNC6_NEOBR Unreviewed; 857 AA.
AC A0A3Q4HNC6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=RNA-binding protein 5-like {ECO:0000313|Ensembl:ENSNBRP00000023636.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000023636.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000023636.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_006783196.1; XM_006783133.1.
DR AlphaFoldDB; A0A3Q4HNC6; -.
DR STRING; 32507.ENSNBRP00000023636; -.
DR Ensembl; ENSNBRT00000024250.1; ENSNBRP00000023636.1; ENSNBRG00000018097.1.
DR GeneTree; ENSGT00940000156617; -.
DR OMA; CESEHER; -.
DR OrthoDB; 298711at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000018097; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12755; RRM2_RBM5; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR041591; OCRE.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034993; RBM5_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR001876; Znf_RanBP2.
DR PANTHER; PTHR13948; RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR13948:SF21; RNA-BINDING PROTEIN 5; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF17780; OCRE; 1.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00360; RRM; 2.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50102; RRM; 2.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 104..184
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 187..216
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 237..321
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 688..718
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 785..831
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..576
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 95668 MW; A68C88C30A072FF0 CRC64;
MGADKRISRT ERSGRYGSDQ CRDESEWRDR RERDQERGEH NMRRWGDERR GDRYEGDRRG
SRESPEQRER KRRNSDRSED GYHSDGDYQE QDYRREPGDE KKSKTIMLGG LSPHVTEDDI
RFAIDQLEGP QPVDVRLMKK RTGISRGFAF VDFYHLQDAT RWMETNQKRL TIQGKTVDMH
YSHPRNKYED WLCSTCGLYN FRRRLKCFRC GAAKAESEAT NNTGVPETQP SGDFYGDTII
LRNIAPMTTV EAIMTALAPY ANLSSNNIRL IKDKQTGQNR GFAFVQLSSP LEASQLLTIL
QGLQPPLKLD GKTIGVDYAK SARKDLLLPD GNRVSAFSVA STAIAAAQWS SSQPQQSSEG
MSEYSYLQEG YTPMSQDYQT YYQQGAAIST SQGNGILGAA PGVKIVPTAV GVVISQNAQV
YQPHIIAQPA VQALPLAQQL EAKPQAGHIS GIEAASLPAA ALAAATVTTA GTLTASEQAA
DTNIAVPDTS TYQYDESSGY YYDPQTGLYY DPNTQYYYNS QTQQFLYWDS EKQTYVPASA
GTGQNDGKTG GSAATGTKEP KEGKEKKEKP KSKTAQQIAK DMERWAKSLN KQKENFKSSF
QPISQEERKE AAAADAGYTL FEKKQVSLDR LIPDMLRAPE EEPSTTSVTS SKCGLVAAYS
GDSDPEEGGA EPDGGDISQD KLTDWKKLAC LLCRRQFPNK ESLIRHQQLS DLHKKNLEVL
RRSKMSEAEL EELERKETEM KYRDRAAERR EKYGIPEPPV PKKKKFNQPA PAINYEQPTK
DGLNSDNIGN KMLQAMGWKE GKGLGRNQQG ITAPIEAQLR TKGAGLGTKG TNYTLSPSDT
YKDAVRKAMF ARFTELE
//
