ID A0A3Q4HNE1_NEOBR Unreviewed; 576 AA.
AC A0A3Q4HNE1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Neuroendocrine convertase 2-like {ECO:0000313|Ensembl:ENSNBRP00000023656.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000023656.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000023656.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
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DR AlphaFoldDB; A0A3Q4HNE1; -.
DR STRING; 32507.ENSNBRP00000023656; -.
DR Ensembl; ENSNBRT00000024272.1; ENSNBRP00000023656.1; ENSNBRG00000018095.1.
DR GeneTree; ENSGT00940000156965; -.
DR OMA; LAKQWHS; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000018095; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016486; P:peptide hormone processing; IEA:UniProt.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR PANTHER; PTHR42884:SF13; NEUROENDOCRINE CONVERTASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 398..534
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 104
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 145
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 321
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 576 AA; 63958 MW; D07B4F7684035A17 CRC64;
EGLFHLYPQD TSKRRSKRSA RRRQQLQKDK RVKNVIEQEG FSRQKRGYRN INDIEVNMSD
PLFTKQWYLI NTGQADGTPG LDLNVAEAWQ LGYTGKGVTI AIMDDGIDYL HPDLASNYNA
DASYDFSSND PFPFPRYTDD WFNSHGTRCA GEVSAAANNN ICGVGVAYNS KVAGIRMLDQ
PFMTDIIEAS SISHMPQIID IYSASWGPTD DGKTVDGPRE LTLQAMADGV NKGRGGKGSI
YVWASGDGGS YDDCNCDGYA SSMWTISINS AINDGRTALY DESCSSTLAS TFSNGRKRNP
EAGVATTDLY GNCTLRHSGT SAAAPEAAGV FALALEANPN LTWRDMQHLS VLTSKRNQLH
DEVHQWRRNG VGLEFNHLFG YGVLDAGGMV KMAKEWKTVP ERFHCVAGSI QEVHKIQSGN
KLVLAITTEA CQGKDNFVRY LEHVQAVVTV NASRRGDLNI NMTSPMGTKS ILLSRRPRDD
DSKVGFDKWP FMTTHTWGED PRGTWVLEVG FQGDEPQRGV LKEWTLMLHG TQSAPYIDQI
VRDYQSKLAM SKKEELEEEL DEAVERSLKS LLSKNN
//
