ID A0A3Q4HP10_NEOBR Unreviewed; 559 AA.
AC A0A3Q4HP10;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Zinc finger CCHC domain-containing protein 8 {ECO:0000256|ARBA:ARBA00022379};
DE AltName: Full=TRAMP-like complex RNA-binding factor ZCCHC8 {ECO:0000256|ARBA:ARBA00032546};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000025335.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000025335.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the ZCCHC8 family.
CC {ECO:0000256|ARBA:ARBA00007497}.
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DR AlphaFoldDB; A0A3Q4HP10; -.
DR Ensembl; ENSNBRT00000025996.1; ENSNBRP00000025335.1; ENSNBRG00000019242.1.
DR GeneTree; ENSGT00390000011475; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000019242; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR006568; PSP_pro-rich.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR13316:SF0; ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR13316; ZINC FINGER, CCHC DOMAIN CONTAINING 8; 1.
DR Pfam; PF04046; PSP; 1.
DR SMART; SM00581; PSP; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 173..188
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT REGION 344..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..376
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 62081 MW; DD81F06859C9F582 CRC64;
MDRVAPGMAE VDFGDSELFQ QLDESAPPVT KHIRPFSAEF VIFSLIPRPH KILRRKMSLL
TRPSGVTVED VNTDGPLLQV LYTNNIISKT CRQEIEDCIC SVILRHHKPD VEKRSSFNIK
PQVVDKLGQP LVNENPQLTD GWDVPTYQQV FNQVIGTDGQ EIEMKDKRPK SMCFNCGSSS
HQLRDCPKPK DMAAINERRK EFNQSNNQAM QSNQRYHADE VEERFAKYKP GVMSEELLTA
LGIDENTLPP LIYRMRQLGY PPGWLKEAEM ENSGLSLYDG NEDVVFFSLT ASNFPGFNVA
APHKMKDEFM HYGSIPMQSS HMKQNYAAYL SSFFPTFQPP LPPGSPCFSS PPPLPQGTPP
ATPTPPPLPK GTPPLTPTNG SPAVRGRDWV VVDETGEGTE DDLTLEELEE QQRLIWAALE
NADMASNSDC ETPAAQTPVP SSPSVSTSAH ADTETEDTDE GMDSIKPEEP SLSKENQPEV
QEGLSLSPGP VKVNDDSPQS PEPAEVQEST PRPTGFGPAV QNLSKFFSSM EENNVASISI
HTSQFLQDEH FQHCLLQNF
//
