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Database: UniProt
Entry: A0A3Q4HP11_NEOBR
LinkDB: A0A3Q4HP11_NEOBR
Original site: A0A3Q4HP11_NEOBR 
ID   A0A3Q4HP11_NEOBR        Unreviewed;       395 AA.
AC   A0A3Q4HP11;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN   Name=GJC1 {ECO:0000313|Ensembl:ENSNBRP00000022553.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000022553.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000022553.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC       {ECO:0000256|RuleBase:RU000630}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000256|RuleBase:RU000630}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC       {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU000630}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the connexin family.
CC       {ECO:0000256|RuleBase:RU000630}.
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DR   AlphaFoldDB; A0A3Q4HP11; -.
DR   STRING; 32507.ENSNBRP00000022553; -.
DR   Ensembl; ENSNBRT00000023148.1; ENSNBRP00000022553.1; ENSNBRG00000017233.1.
DR   GeneTree; ENSGT01090000260005; -.
DR   OMA; VRWKQHR; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000017233; Expressed in testis and 1 other cell type or tissue.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; CONNEXIN; 1.
DR   PANTHER; PTHR11984:SF6; GAP JUNCTION GAMMA-1 PROTEIN; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW   ECO:0000256|RuleBase:RU000630};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000630};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          42..75
FT                   /note="Connexin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00037"
FT   DOMAIN          200..266
FT                   /note="Gap junction protein cysteine-rich"
FT                   /evidence="ECO:0000259|SMART:SM01089"
SQ   SEQUENCE   395 AA;  44657 MW;  083E2C318813B151 CRC64;
     MSWSFLTRLL EEIHNHSTFV GKIWLTALIV FRIVLTAVGG ESIYYDEQSK FVCNSAQPGC
     ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAVNKIA RAEEKAESGG VNGFSQKKPK
     KHYLAGRKQH RGIEEAEDDD EEDPMIYEVA EVENDDCEAE KGGSCDRKVK AKVRHDGRHR
     IKEDGLMRLY VFQLLLRSLL EVAFLCGQYA LYGFSVPATY VCKDQPCPHK VDCFVSRPTE
     KTIFLLIMYT VSLLCLALNI WEMLHLGIGT MYEIIHSRKT ELPNEDSYPF SWNAPAPPPG
     YNIAVKPPLG NHNQPLPITD LTNAKLASEH GLNLADIEWF LAVLTSRVAR LNLELRSCVL
     VVILRDRNSN CCSLKQFFVN IVARKLIYTL AGFVA
//
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