ID A0A3Q4HPZ1_NEOBR Unreviewed; 1614 AA.
AC A0A3Q4HPZ1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Protein polybromo-1-like {ECO:0000313|Ensembl:ENSNBRP00000022953.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000022953.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000022953.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 32507.ENSNBRP00000022953; -.
DR Ensembl; ENSNBRT00000023553.1; ENSNBRP00000022953.1; ENSNBRG00000017496.1.
DR GeneTree; ENSGT00390000003017; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000017496; Expressed in blood and 8 other cell types or tissues.
DR GO; GO:0016586; C:RSC-type complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR CDD; cd04717; BAH_polybromo; 2.
DR CDD; cd05524; Bromo_polybromo_I; 1.
DR CDD; cd05517; Bromo_polybromo_II; 1.
DR CDD; cd05520; Bromo_polybromo_III; 1.
DR CDD; cd05518; Bromo_polybromo_IV; 1.
DR CDD; cd05515; Bromo_polybromo_V; 1.
DR CDD; cd05526; Bromo_polybromo_VI; 1.
DR CDD; cd21984; HMG-box_PB1; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 6.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR037968; PBRM1_BD5.
DR InterPro; IPR037382; Rsc/polybromo.
DR PANTHER; PTHR16062:SF19; PROTEIN POLYBROMO-1; 1.
DR PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00439; Bromodomain; 6.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00297; BROMO; 6.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47370; Bromodomain; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 5.
DR PROSITE; PS50014; BROMODOMAIN_2; 5.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 66..128
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 218..288
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 387..457
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 522..592
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 659..729
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 940..1058
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1131..1247
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1352..1402
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1352..1402
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1298..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1454..1518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..188
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..909
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1312
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1614 AA; 185786 MW; E4A04707B471C8DF CRC64;
MSASSKRRRA TSPSSSVSGG GDLDDVSSST PGSGRKRKRV SNVPPVDTIA VCHELFNTIR
DYKDDQGRQL SEVFQRVPKR RNQPDYYEVV SQPIDMTKIQ CKLKSEDYND VEQLTADFQL
LFNNARSFYK VAFTYVCISQ CKPYRDSEEY QAACKLWEVY FQTRNEFVQP GDRDEDDEDG
DDMDNPGMAT EEEVSPHYIL KEVLEQLLEA IVSHADPSGR LVSELFQKLP SKVHYPDYYA
IIKEPIDLRT IAQRIQIGYY KNVNAMAKDV ELMTKNAKTY NEPGSQVFKD ANTIKKVFIQ
RKTELEHAEP TKSSLRIRNR RSGQGDRISG VSVALQYGSE SEDDPVLSGS VCYDEGESEA
ESQSSSMEMS NPIFQLYEAV RGARNNQGQM FSEPFQQLPS RREYPDYYQQ IKQPISLQQI
RAKMKNGEYE SVEQIEADLN LMFENAKRYN MPNSSIYKRA FRLQQIMQAK KRELLRRDDE
DGDSILSSDA GSVKRKSHKK NVKKNRMKAF YAAVTEAREA GTNRRLCDLF MVKPSKKDYP
DYYNVILEPM DLKTIEHNVR NERYATEEAL MEDMKLMFRN ARHYNEEGSQ VYNDADILEK
ILKDKRKEMG PPPEEEDVGS PKLKLRKSGV SPKKSKYLTP LQQRLNELYD AVRNFTDRRG
RRLSAIFLRL PSRAELPDYY ATIKRPIDME RVRSHMAAGR YQDVDALVED FALMFNNACI
YNEPESLIYR DALVLHRVLL ETRKQQEGGE EFGPPGVGLL VRELIRNLFV SVMGHQDEEG
RCYSDSLAEI PAVDPAAPEK PPLNFDVIKM NVERGRYRRL DVFQEHMFEV LEKARRLHRT
DSEIFEDAVE LQQFFIKIRD ELCKNGEILL SVALNYTLKH LHSDVDQEKR EKIPKEIEED
KQKKDEDENQ EDEKPEDLAG EVWQSKPEHV YSQDCRFENS TYHVGDFVYV EPSEPNLKPH
IVCIERLWED EAGEKWLYGC WFYRPSETFH LATRKFLEKE VFKSDYYNKV SISKVLGKCV
VIFVKDYFKM QPEGFRPEDV YVCESRYTAR NKFFKKIKIW AMPESSFKLV PREAPLPVVR
VASMFVKPDQ EKPLAYTVNG FVEKEREDVP TEMSGAEPGC QYYEQLCYKN MWFKVGDCVY
IQSHGLSKPR VARIEKLWQQ NGTTFFFGPI FIHPEETEHE PTKMFYKREV FLSHLEETLP
MTCVIGKCVV SSFKDYLSCR PTELSEDDVL LCESRYIESE KMMKKFKGLK RFSYSSKVVE
DEIYYFRKLI VPQKEASPIL DKKIDELEVK LADMEDADDD MEDMDEDEEA PETPSLPQMQ
TPLTNDMDVM PYTPSQTTPK VKGLSKKEGA KRKINMSGYI LFSSEMRAVI KARHPDFSFG
ELSRLVGTEW RNLEASKKAE YEGMMGAYGP PYMPMQGPHE GLLSVAPMPP HPTGGPHLPP
HHLQQGMPGY PGMPHQGKGH CPSRTCSVTS SRVSPAGGGL PGPQQVSLSP GMFSPGQHAP
PPYPGQGQLG QPSHLQPTTP MFVAPPPKTQ RVLHSEAYLK YIEGLNSDSS TVSKWDQALK
AQRRDSHLTK EQESRLPAHW LKSKGAHTTM VDALWRLRDL MLRDSLNICQ AHNL
//
