ID A0A3Q4HQ52_NEOBR Unreviewed; 955 AA.
AC A0A3Q4HQ52;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Solute carrier family 12 member 3-like {ECO:0000313|Ensembl:ENSNBRP00000022988.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000022988.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000022988.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3Q4HQ52; -.
DR Ensembl; ENSNBRT00000023588.1; ENSNBRP00000022988.1; ENSNBRG00000017195.1.
DR GeneTree; ENSGT00940000155044; -.
DR Proteomes; UP000261580; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002948; SLC12A3.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF9; SOLUTE CARRIER FAMILY 12 MEMBER 3; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01230; NACLTRNSPORT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..107
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 141..642
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 672..772
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 824..954
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 90..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 955 AA; 104773 MW; 6F62D2BE62D46B38 CRC64;
MELQGANDGI RLAAYRASLP APVANGKATS GGFESDYYTC DGDGSSVASR VSVDLTGYET
LDAPPRYDFY ANTEVWGRRR QFRPSLFQLH AGPEQDDSRP PMYEETTGGQ AEAGGQDSSE
EDEDEQKEPP SEPTRFGWVQ GVMIRCMLNI WGVILYLRLP WITAQAGIGL TWIIILLSST
ITGITGLSTS AIATNGKVKG GGTYFLISRS LGPELGGSIG LIFAFANAVA VAMHTVGFAE
TVTDLMRENG AVMVDRTNDI RIIGIITVTC LLGISMAGMA WESKAQVLFF IVIMVSFASY
IVGTIIPASP EKQSKGFFSY KANIFAANFV PDWRGPGGSF FGMFSIFFPS ATGILAGANI
SGDLKNPAVA IPRGTLLAIF WTTVSYLIIS ATIGSCVVRD ASGVLNDTLS SAVEDCVGTA
CQYGWDFTEC INNKTCVYGI HNYYQSMSMV SAFGPLITAG IFGATLSSAL ACLVSAPKVF
QCLCKDQLYP LIGFFGKSYG KNNEPIRGYL LTYIIAACFI LIAELNTIAP IISNFFLCSY
SLINFSCFHA SITNSPGWRP SFRFYSKWLS LLGAICSVVI MFLLTWWAAL IAFGVVFILL
AYTLYKKPDV NWGSSVQASS YNMALSRCAG LNSVEDHVKN YRCSVEDCSG LMKSFSLPPR
VSQDGPSPSV LEKATSDSHL NWLNKRKVGS FYRGVVAADL QSGVNVLLQG AGLGRVKPNV
LIMGFKKDWR SDTPQAAHNY IGVIDAFDLQ FGVCVLRMRE GLEVSSPSQS HGESLHAYHS
RLHVNAPGNP EPQHSTQFQK KQGKKTIDVY WLSDDGASRS LSRVLELIKK FRLGFHSVEV
LPEINQPPQQ MNVHQFEKMV SRFRVDTNSK PDSDSGCASQ HQEPWMITDQ DFEKNKAKSL
RQIRLNEVLL DYSREAALII TTLYLAWLDF LSRDLRPPVL LVRGNQENVL TFYCQ
//
