ID   A0A3Q4HQU9_NEOBR        Unreviewed;       515 AA.
AC   A0A3Q4HQU9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=TIR domain-containing adapter molecule 1-like {ECO:0000313|Ensembl:ENSNBRP00000024541.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000024541.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000024541.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q4HQU9; -.
DR   STRING; 32507.ENSNBRP00000024541; -.
DR   Ensembl; ENSNBRT00000025187.1; ENSNBRP00000024541.1; ENSNBRG00000018724.1.
DR   GeneTree; ENSGT00940000163706; -.
DR   OMA; TRHGWQD; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000018724; Expressed in skeletal muscle tissue and 2 other cell types or tissues.
DR   GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.25.40.780; -; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR046946; TCAM1/2.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR040886; TRIF_N.
DR   PANTHER; PTHR47230; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1; 1.
DR   PANTHER; PTHR47230:SF1; TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1; 1.
DR   Pfam; PF17798; TRIF-NTD; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT   DOMAIN          298..450
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          178..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..241
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..276
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  57199 MW;  422986CED55AB856 CRC64;
     MLLLISEVLL KMSLKSQANH GTGLRDVFDL LVKTPSERLL SLTFQLGDSP EDKIIHALCL
     IVLDKEVEAL DKLQMLTDSS LAKHVAEKCQ MRGGNLEDFG SHCGLFEALT GESLAELAHV
     FKVLTEQRLC DPLLRNLAYK RALSSDCVKT RNGNDLELYN YKFLEEAKNV CGPECAEWMS
     PSSDQRAEPD SNLLTSSLPS PLSANLPSIV KENRAQNVTE PPQSSEAQPE TTESPPFDPK
     QDSSKYGTPA AAAASLMSNE SDTKSDNQTK TPSPKLPKTS VPGEIHESKA VEEEEEEIFY
     AFVILHAPED SDMAESIKEK IEAVIGGEFE GATFSDFSIP GKTTIKSMED AINNSAFTLL
     LLTRNFNTCM LDLKANAAFV NSINKAHKYN TVIPLLPREN CMPKQDMPMV LQGVNPLEER
     KNFEKKIQKS LLPAKIKRQR WIWKQEKAQK QTMKHLNKIS NLTISVEPNL RPGPPTAAWH
     PQPNIHIENA NYIMIGNDSR MNVDLGGNAN REDSN
//