ID A0A3Q4HSN8_NEOBR Unreviewed; 630 AA.
AC A0A3Q4HSN8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Uncharacterized LOC102793407 {ECO:0000313|Ensembl:ENSNBRP00000025246.1};
GN Name=SOCS7 {ECO:0000313|Ensembl:ENSNBRP00000025246.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000025246.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000025246.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; A0A3Q4HSN8; -.
DR Ensembl; ENSNBRT00000025903.1; ENSNBRP00000025246.1; ENSNBRG00000019246.1.
DR GeneTree; ENSGT00940000156314; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000019246; Expressed in blood and 8 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10388; SH2_SOCS7; 1.
DR CDD; cd03741; SOCS_SOCS7; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035866; SOCS7_SH2.
DR InterPro; IPR037346; SOCS7_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF5; SUPPRESSOR OF CYTOKINE-SIGNALING 7; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 443..552
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 547..597
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 10..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..339
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 67602 MW; 0EE1A52285DDE3F6 CRC64;
MVLQNLLRSG DRILECGLEQ PPPGFLQEEA ERQRQQLDPV PGTGPGSATP GPGGGKDQNP
PAQENLQPQQ LLQWHPVLRL GSQAPQRGVP ALDSESGSVL CHTHHLLTDR LAKWPPGLLD
QALRAGLLEP RKTCPPRCQD PVLAPAQRPV HPGEVREGSG GQELVLSLPR CSCHGVLASG
SGGIGPGEDP SETSDALLVL EGLGSEEVGG LAAESGDAEG EDTEKTERVV GAGTPGGAGT
VFSSGTLSGL MRQVHRLAEE AGVCTDQSCR SSLAVLGATV TATPCPYLPS RSQPQSRAAT
PKLGVASGGA GRSASPLVVL EGEGGARGRE GEKMPRGKSR KGGSLKVRLS KLFRTKSSSG
GSGGLLDKRP SLASSTSSGG SLLDVWGSTC SNPDQDGETV SLVDVDISRR GGNSLHPPTP
PPPPRRSLSL LGTSSFFLLP CGWYWGPMNW EDAEMKLKGK PDGSFLVRDS SDPRYILSLS
FRSQGITHHT RMEHYRGTFS LWCHPKFEDR CHSVVEFIER AIMHSKNGKF LYFLRSRVPG
LPPTPVQLLY PVSRFSSVKS LQHLCRFCIR QLVRIDHIQE LPLPTPLIAY LRKFYYYDPE
EEISPTLKED KEQKERGTEG GGQPGVESQT
//