ID   A0A3Q4HTI5_NEOBR        Unreviewed;       271 AA.
AC   A0A3Q4HTI5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Homeobox protein {ECO:0000256|PIRNR:PIRNR000563};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000024308.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000024308.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR000563}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000256|PIRNR:PIRNR000563}.
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DR   AlphaFoldDB; A0A3Q4HTI5; -.
DR   Ensembl; ENSNBRT00000024946.1; ENSNBRP00000024308.1; ENSNBRG00000018586.1.
DR   GeneTree; ENSGT00940000154518; -.
DR   OMA; HESGCKG; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000018586; Expressed in zone of skin and 2 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0021984; P:adenohypophysis development; IEA:Ensembl.
DR   GO; GO:0070306; P:lens fiber cell differentiation; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR016233; Homeobox_Pitx/unc30.
DR   InterPro; IPR003654; OAR_dom.
DR   PANTHER; PTHR45882:SF2; PITUITARY HOMEOBOX 3; 1.
DR   PANTHER; PTHR45882; PITUITARY HOMEOBOX HOMOLOG PTX1; 1.
DR   Pfam; PF03826; OAR; 1.
DR   PIRSF; PIRSF000563; Homeobox_protein_Pitx/Unc30; 2.
DR   PROSITE; PS50803; OAR; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|PIRNR:PIRNR000563};
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR000563};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR000563};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT   DOMAIN          233..246
FT                   /note="OAR"
FT                   /evidence="ECO:0000259|PROSITE:PS50803"
FT   REGION          1..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  29805 MW;  80003B28711B8320 CRC64;
     MDFNLLTDGD PRSPALSLSD SGTPQHDPGC KGLDQSGHEN RSTHRKVRAE RKHLGTQSTN
     EPRKPKCNTH RSRDYQNKTG NVWFKNRRAK WRKRERNQQA ELCKNGFGAQ FNGLMQPYDD
     MYTGYSYNNW ATKSLAASSP LSAKSFPFFN SMNVSPLSSQ PMFSPPSTIP SMNMASSMVP
     TAVAGVPATS LNNLGNLNNL NSPSALNSVA VTAATCPYAT TASPYMYRDT CNSSLASLRL
     KAKQHTNFAY PAVQNPVSNL SPCQYAVDRP V
//