ID A0A3Q4HTW8_NEOBR Unreviewed; 686 AA.
AC A0A3Q4HTW8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Hypoxia-inducible factor 1-alpha-like {ECO:0000313|Ensembl:ENSNBRP00000020937.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000020937.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000020937.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_006805238.1; XM_006805175.1.
DR STRING; 32507.ENSNBRP00000020937; -.
DR Ensembl; ENSNBRT00000021502.1; ENSNBRP00000020937.1; ENSNBRG00000016073.1.
DR Ensembl; ENSNBRT00000021508.1; ENSNBRP00000020943.1; ENSNBRG00000016073.1.
DR GeneID; 102782689; -.
DR CTD; 393376; -.
DR GeneTree; ENSGT00940000166085; -.
DR OrthoDB; 5396877at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000016073; Expressed in mesonephros and 8 other cell types or tissues.
DR GO; GO:1990907; C:beta-catenin-TCF complex; IEA:Ensembl.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR GO; GO:0048821; P:erythrocyte development; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0014823; P:response to activity; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF34; HYPOXIA-INDUCIBLE FACTOR 3-ALPHA ISOFORM X1; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 17..70
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 117..171
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 277..316
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 79..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..110
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..412
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 77086 MW; B60A9CE884CC7D32 CRC64;
MEKKEGVVAV KRTSTEQRKL RSRDAARCRR SQETEVFYEL AHTLPLPRRV STHLDKAAIM
RVTLSFLRMH HLLRSDKNLK EEPKEVAEEE EEEEVKVEEE EEEEEKDEDP MDAFYPQALA
GFIMVMTEEG DMIYLTENVN KHIGITQLEL LGQSIYDFVH PCDQEELRDL LTPRPGLSKK
SRTEQTSERN FFMRMKSTLT TRGRTVNIKS ATWKVLHCTG HIRPFGSGSA SPPAGRVMTL
LCEPIPHPSS VEFPLDTCTF LTRHSMDLRF THCEGRVAEL VGYKPDDLIG RSGFEFLHAL
DSDHINKSLH TLLSKGQVST SQYRFLANNG GYVWAETQAT VLYNSKTSQP DAIVCLNFIL
SSVEQPDVIF SMEQTRCSRR SKVEPADEDS GTADMCESKT DSEPRTVSTE AEDVDSDSSS
SATLFMELQE KPEELLQLAP DAGDTIVPLS PGSVELSFAS PPSPDSVPEH PQDLCTPQLR
KLLAPIFDPI TPPLSASSSS PSPSSSPKPE QSRSEEEVMD TSEVEKFFAF WPEDAQKKET
PVEMEGMDLD MLAPYISMDD DFQLTFLSSM TEEAEKPSET SATSRKRTHD SAEEMLSPVM
LQDKRQKKDP SMEEELLLTH KLLDSLDETD RPDLIMDPRP ESRSHLLTDR DPVLGGMQGL
CDTAALMKDI FVSRPTLLSP PLSPMT
//
