ID A0A3Q4HVK7_NEOBR Unreviewed; 3891 AA.
AC A0A3Q4HVK7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Extracellular matrix protein FRAS1-like {ECO:0000313|Ensembl:ENSNBRP00000021687.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000021687.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000021687.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR STRING; 32507.ENSNBRP00000021687; -.
DR Ensembl; ENSNBRT00000022268.1; ENSNBRP00000021687.1; ENSNBRG00000016480.1.
DR GeneTree; ENSGT00940000163761; -.
DR OMA; NSGMRVQ; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000016480; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0071711; P:basement membrane organization; IEA:Ensembl.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR GO; GO:0010669; P:epithelial structure maintenance; IEA:Ensembl.
DR GO; GO:0033334; P:fin morphogenesis; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd00064; FU; 12.
DR Gene3D; 2.60.40.2030; -; 5.
DR Gene3D; 6.20.200.20; -; 4.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 10.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF00093; VWC; 4.
DR SMART; SM00237; Calx_beta; 5.
DR SMART; SM00261; FU; 14.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 4.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF57603; FnI-like domain; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR PROSITE; PS50268; CADHERIN_2; 1.
DR PROSITE; PS51854; CSPG; 11.
DR PROSITE; PS01208; VWFC_1; 5.
DR PROSITE; PS50184; VWFC_2; 6.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00043};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3786..3807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..65
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 70..130
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 134..194
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 196..256
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 260..320
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 324..387
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REPEAT 1073..1173
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1239..1350
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1375..1471
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1507..1602
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1623..1724
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1747..1849
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1871..1971
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1992..2091
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2113..2205
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2225..2318
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 2249..2356
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REPEAT 2353..2450
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
SQ SEQUENCE 3891 AA; 429428 MW; 468BDFF1F960F565 CRC64;
EIAVCCHVFY PISNNTSWRP QSCQECTCYG DVAICEPTHC PNPHCDLQRG EHLRIPTNKC
CPECASSSQG SCQYEGVTYA HDSQWSPSPC SVCTCSGGSV SCSTRPCPHL TCPEDQSLFT
PAGECCPKCG SSGESCSWQG IVYRDGEEWK PSLCSRCVCS NGEVQCSVAE CQQVACKPHE
NLVIQPGECC PQCVSNPCLS AGKQYQHGEQ WQKNTCTMCV CDRGQSKCHT KTCPPITCDK
GQTKVKRAGQ CCDECAAAKG SCQYQGAVRY HGDMWNSTGC EFCTCSRGQV LCQRAECGRV
ECPQGSELVN LPAKCCPECS SAKPSCVHKG KSYKVLLSQN LARWSDGSCR ECECHDAQVT
CYLRSCRTCP LGTLAVIQDG QCCPECHQVQ CHADCLSCSG TPDHCDSCRD PQALLHLGRC
LSVCPVGFYA EGRVCAACQS SCATCSSRWD CQSCGSRLPL LNPDRSQCLA SCPPGSYQHD
PTHCRYCHES CSECRGPSQQ ECASCSDPAA LLKDGACVLD CGTGFYSREG VCHACDSSCA
SCFPDNPKCM SCPPGTALHH GKCLSQCPAQ HYLDSQSRCR ACHSSCASCW GPSVSQCTLC
PGGLLLHQGQ CVEACGEGLY AQDYTCHNCH PSCRSCVGPL ASDCLRCLKP EEALLPQSSH
LQHSVCTAGC PTRSFLDDMQ TCRECHPSCW QCAGPSADNC TSCPSPSSLY EGRCVPTCPQ
GFFIQDNQCQ ACHPSCQTCS GPSQADCIAC PQLVSLQSGH CRANCQEGHF LNAISGECVK
CSSDCQRCTA DLQTGVGSIC LWCKVPRMWL LGDHCVSRCP LGHYGWHGAC IECHPSCEAC
SGAGPLSCTS CPANSVLLPS GLCAPKCPLG YYNNGQRICQ ACDSQCLTCE TPGVCTSCRD
PAKVLLFGEC QYDSCAHQYY LNTTSRTCRE CDWSCNACKG PLRTDCLQCM EGYVLQEGVC
TQGCSFGAYQ DGDRCLGCDD HCLDCRGPGQ CQECQPPYAT LHGQCVLECG RNYFLDASSK
ACKSCSSDCV LCDGIGLCRA CRNQTYLMEG YCTPDCGHGY YADQKTRTLN AHTPALHVNG
SLLVPFDGFA PLLPTLLQVK DPDSPSEQLI FQLVQKPSNG RLVLFRGEEG EETGGQEIKK
DDTFTWAELR HGRVRFQYQR DKDRNGEFTV RVADPQLFSQ PKTIQVRAVS MQVTVGFIIR
GWEAAHSTSQ HSVTPPYNFA WSALHGEMLK FLSLPLCNSP HMLSIPVTWV KEGGMVRLDK
KYLQTDFKGV STDNIVYSIL PSEGQPKYGE VLLVSMPADG PPEGWLPSLT DDRSFTATTS
FTQQDVNDGA VWYRHFGTGS SGDSFLFQVS SEAEPVVQSD AQTFTIGVMP QIPGFPQLAP
DCDLQITALE DQVTEITPSA LSFVDSETPS EKLIYSITKP LPSGQGTIEH RDRPYTHVQH
FTQADVSNGK IIYRPPQAPS HLQELYQYSF TGLPESLSVY FTVSDGEHTT PELDFAVLLL
TNHQQPPVFQ VLDPLLEVSV RGQAAIGGQQ LAVSDVDTAP DELEFEVVEA PVHGELIKTD
GNTKIRMTNG DTFTFSDVTR NVLLYHHSGL STQDDAITFS VSDGISMAAT VVQVVVLGAG
GSGPQQDPIA TLSLEVGEKS STVIRRSHLA YTDDSSPDDQ IRLQLVSVPM YGILTRSQSQ
QEHQELREYS TFTMEDINKH RIRYITSIET GSQPVTDIFH FVVYDGDNNR LDTQICTITI
TSAPRQPPLV TVRSSIKVEE GGRVQLSTND ITVSHVDTPP KDLLIWLVSP PKYGFLENTR
RGSSVGGSHV VTPDVPFSVE DLTSGHISYV QESQLTPQTK QDIFSVYISD GLSQTEAFSV
EIDIQQSKED KEPVVSVSSI HIEENSGVVI TNSSLSVLDQ DTPENEILFT IIRIPSYGKL
RRRQFYSQPL ENGRVLTQGS TFTYQDVVDQ LLVYTPETVS GGADEMAFTL TDGIYTHTGR
LEFTMDVTRS EGPRMTVNRG LQLPAGSSSK ITEQNLKGTD IDSDHLKLRY ILTKDPPVGK
LQLNRSSRAE TVSVRGPIQS FTQEDVNKGL LQYSHEKGEK GGSLSFKFNL LDPEGNKLID
QSFFISVLED HLPPSVVVNK GLVLDENSVK KLTTLQLSAS DQDSEPGELI YRVTKQTSLG
HLEHAASPGT RISTFTQADL ASRSIQYVHT SEEEKHADQF SFTVSDGTNE VAQTFYITIK
PVDDSLPLLQ VPGMRVQEGV RKTITEFELK ATDADTEAES VVFSVVQAPR HGTIERTING
QHYRQTSSFT MDDIYQNRIS YNHDGSNSLK DRFTFTVTDS TNLLFMVEDD GKEIVTAAPQ
KFKIDILPVD DGTPLIFTNL GLQWLEYMDN KATNLITKKE LLTMDPDTDD GQLVYEITTE
PKHGFLESKL KPGNPITTFT QADINLGLIR YVLHQENVQE TMDNFKFLVK DSKPNVVSDN
VFHIQWSLIS FEHKSYNVSE KAGTVAVTVK RTGNLNQYAI VLCRTEQGSA TSTSSVGSRP
GQQDYVEYAG QVQFDEREDT KVCTIVINDD KVFEGIESFH VELSMPVYAL LGGNTRAVVN
INDTEDEPTL QFDKKIYHVN ESSGLIHAPI ERKGDTSSTV SALCYTVAKS AQGSSLHALE
SGSDYKSRGM TTDNRVIFGP GVSMSTCDVK LIDDSEYELS EEFELVLSDT SDNARMGDVS
VAKVIIDGPN DASTVSLGNA TFTFSEDAGT IEIPVLRHGS DLSSLTSVWC ATRPSDPPSA
SPGVDYIPSS KKVEFKPGKT DETCSLTIMD DIQNPSIEGS ESFVVFLSSP QGAVLQEPYE
ANVIITDTFQ DIPNMQFEKS SYTVKEKDNL LHIPIIRTGD LSFKSSVRCF TRTMSAMVMD
DFEERRNADE SRITFLKGEK VKNCTVHITD DSVQTSPVPP APTIEFEQAS YQVREPPGPD
GIEVLNIKVI RRGDLDRTSK IRCSTRDGSA QSGVDYNPKS RVLKFTPGMD HILFKVEILS
NEDREWHESF SLVLGPDDPV EAVLGEITMA TVTILDQEAA GSLILPATPI VVSLADYDHV
QEVIKEGSKK TPSPGYPLVC VTPCDPHYPK YSVMKERCEE AGINQTQVHF SWEVAAPTDT
SGARSPFETV TDTTPYTSVN HMVLDSIYFS RRFHVRCVAQ ARDKAGHLGT PLRSNIATIG
TEGSICHTPV TTGTARGFQA QSFIATLKYL DVKHKEHPNR IHISVQIPHQ DGMLPLVSTM
PLHNLHFLLS ESIYRQQHVC SNLVTLKDLQ GIAESGFLDD VSYDSISLGP GYDRPYQFNP
NVREGKSLQF YKHLNLKSCI WTFDAYYDMT ELIDVCGGSV TADFQVRDSA QSFLTVQVPL
YVSYIYVTAP RGWASLEHHT EMEFSFFYDT VLWRTGIQTD SVLSARLQII RIYIREDGRL
VIEFKTHAKF RGQFVLEHHT LPGHKSRLMA PDHLGGIEFD IQLLWSAQTF DSPYQLWRAT
SSYSRKDYSG EYTVFLVPCT VQPTQPWIDP GDKQLSCTAH APEKFLVPIA FQQTNRPVPV
VYSLNTEFQL CNNEKVFMME PATADVSMAE MDYKGAFSMG QTLYGRVLWN PEQNLNAAYK
LQLEKVYLCT GRDGYVPFFD PTGTLYNEGP QYGCIQPNKH LKHRFLLLDR KQPDVCDRFF
HDVPFEAHFA SDIPELQSMT AMPGVDGFTM KVDALYKVEA GHQWYLQVIY VISPESRSNP
RIQRSVTYQL SRSKRDLVDR SGRLTLDESL IYDNEGDQIK NGTNMKSLYL EAGPSPTFNA
HVGSSVGGGV AAITLLVLVL LASCFLFRRC RRLAKKKSKK KEPKIYEEYP LNTKVEVCMD
KCVEKNFGTK HCTVRNINVL NRNQEANSKA KVKQVNLEVK LHNNLNDGTE V
//
