ID A0A3Q4HVU7_NEOBR Unreviewed; 2522 AA.
AC A0A3Q4HVU7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Teneurin-2-like {ECO:0000313|Ensembl:ENSNBRP00000025233.1};
GN Name=TENM2 {ECO:0000313|Ensembl:ENSNBRP00000025233.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000025233.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000025233.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 32507.ENSNBRP00000025233; -.
DR Ensembl; ENSNBRT00000025890.1; ENSNBRP00000025233.1; ENSNBRG00000019217.1.
DR GeneTree; ENSGT01030000234566; -.
DR OMA; STHILAW; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000019217; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF8; TENEURIN-2; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF05593; RHS_repeat; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 2.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 2.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 189..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..189
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 482..514
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 549..584
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 504..513
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 553..563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 574..583
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2522 AA; 278876 MW; 46F0711A8EEB65F5 CRC64;
MHSSSDLVSI CQKSSPPPPP LPLTHTHVNR QISKRKSRQE SSAHPHFSLP LARAANHQSQ
TTLRPPLPPP HNHHTLSHQS ANSLNRNTLR GGRNPIHAPA PGTGDGPTTP ESVQLQDSWV
LNSNVPLETR HFLFKTSSGT TPLFSSSSPG YPLTSGTVYS PPPRLLPRNT FSRSAFKLKK
PSKYCSWKCA AVTAIAAAAL LAILLSYFIA INLLGLTWQL KPSDGPVLNN GLGAGLPVNS
DVATLPSGGR GPWAGRNSSI DSGSIEVGRR VTQEVPPGVF WRSLLHLSQP QFLKFNISLG
KDALFGVYIR KGLPPSHAQY DYMERLDGKE KWSVVESPRE RRSIQTVVLN EAVFVQYLDA
GAWHLAFYND GRERETVSFS TNVMDSVQEC PRNCHGNGEC NSGVCHCFPG FHGMDCSKAA
CPVLCSGNGQ YDKGSCVCYS GWKGPECDVP VTQCIDPLCS GHGTCTDGNC VCSVGYKGPN
CAEVDCMDPT CSNNGICVNG ECHCKPGWGG LHCELPRAQC PDQCHGHGAF IPDTGLCSCD
PNWMGPDCSM DGCPNLCNGN GQCTMGQQSW HCECQTGWRG PGCSVAMETS CADNKDNEGD
GLTDCMDPDC CIQSPCQNSP LCRGSRDPLL VIQQSPMSQP RVRSFYDRVK MLVGRDSTHI
IPLENPFNSS LASLIRGQVL TTDGTPLVGV NVSFVNYPHY GYTLTRQDGM FDLIANGGAS
LTLRFERAPF LSQERTVWLP WSQFYAMDTL VLKTEENTIP GCDLSGFVRP DPLVIASPLS
SFFSSKPGEK PIIPETQVLH EQIEVPGTSL KLCYLSSRTQ GYRSLLKVTM TPAVVSMGLL
KVHLMVAVEG HLFQKWFHAS PNLAYTYIWD KTDAYGQRVY GLSEAVVSVG YEYESCASLI
LWEKRTALLQ GYELDPTNLG GWSLNKHHIL NTRSGILHKG SGENIFVTEQ PPVITSIMGN
GRRRSISCPS CNGLADGNKL LAPVALAMGI DGSLYVGDLN FVRRVYPSMN TTGILELRNK
DFRHSNNPTH KYFMAVDPVS GALFISDTNS RRIYRVRSLT GGRLLSDNAE VVAGTGEQCL
PFDERCGDGG KATEATLMSP KGIAVDKNGL MYFVDATMIR KVDQNGIIST LLGANDLTAV
RPLSCDTSMD VSQVRLEWPT DLAVNPMDNS LYVLENNVIL RITENHQVSI IAGRPMHCQV
PGIDYSLSKL AIHAALESAT AIALSHTGIL YIAETDEKKI NRVRQVSTNG EISLLAGAAS
DCDCKNDVNC NCFYGDEGYA PDAGLNSPTS LAVSPDGTLF IADLNNIRIR AVRANRPGPA
LSSVGYVGSA QYEVASPREQ ELYVFNGEGL HIQTVSLVTG EPLFNFTYSP DGELAMLVDN
CNNTVKVRRD GLGQGGGAGL LRLVLLPENQ VVTLALDPSG GLRSVSALGQ EVALMSYSGN
TGLLATKADE TGWTTFYQYD SEGRLTNVTY PTGMVTSLHR EIERSINIDI ESSSRDDDVT
VITNLSSVEA SYTVVQDQVR NSYQLCNNGT LRVMYANGMG ISFHTEPHIL AGSVSPTIGR
RNITLPTDNG LNSIEWRLRK EQTKGKITVF GRKLRAHGRN LLSIDFDRNT RTEKIYDDHR
KFTLRIMYDA QGRPAMWLPS SSLAVVNVSY SATGQLVGLQ RGSMSERTEF DPQGRILSRS
FVDGKVWSYS YLDKSMVLLL QSQRQYVFEF DASGRVTAVT MPSVARHTMF THVSVGYIRN
TYNPPESNAS IIHDFSEDGR PQAVHYLGTG RRVLYKYGKL TKLSEIIYDS TAVTFGYDET
AGVLKMVNLQ SGGFSCTIRY RKMGPLIDKQ IYRFSEEGMV NARFDYTYHD NSFRIASMKP
VISETPLPVD LYRYDEISGK IEHFGKFGVI YYDINQIITT AVMTLSKHFD THGRIKEVQY
EIFRSLMYWM TVQYDSMGRV VKRELKIGPY ANTTQYRYDY DGDGQLSGVK VNDWSTWRYS
YDLNGNLHLL NPGNSARILP LRYDLRDRIT RLGDVQYRLD EDGFLSQRGT DVFDYNSKGQ
LLRAYNRGPG GWSVVYHYDG LGRRVSTRNS LGQHLQFFYA DLNHPTRVTH IFNHSSSDIS
SLYYDLQGHL FAMEVSSGEE YYIASDNTGT PLAVFSSNGQ MIKQVQYTAY GEVYLDSNPE
FQLVVGFHGG LYDPLTKLVH FTQRDYDVLA GRWTSPDYSM WPKIGKDPAP FNLYMFKNNN
PLSDMLDVKN YVTDVKSWLV MFGFQLSNII PGFPRHSLYF VEPPYELQAT QHCENGQLIT
GVQQAAERHN QAFMALEGRL LNKERRRRKD KPGHWFGTST PIIGRGVMVA LQEGRVVAGV
SALASEDSRK VALVLNGAQY LEGTHYTQDG KDCHYFVKVG SADSDLLALG LTNGRKSLES
GINVTVSGRS RRGVTVEFAV PSLLLSVRYG LAADVLDEEK VRLLELARQR ALAGAWAKEQ
QRARDGKGGS RLWTEGERQQ LLTTGRVQGY DGYYVLPVEQ YPELADSSNN IQFLRQNEMG
KR
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