ID A0A3Q4HWJ4_NEOBR Unreviewed; 2038 AA.
AC A0A3Q4HWJ4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Myoferlin-like {ECO:0000313|Ensembl:ENSNBRP00000028355.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000028355.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000028355.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR STRING; 32507.ENSNBRP00000028355; -.
DR Ensembl; ENSNBRT00000029097.1; ENSNBRP00000028355.1; ENSNBRG00000021525.1.
DR GeneTree; ENSGT00940000154741; -.
DR OMA; DLLVVEX; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000021525; Expressed in zone of skin and 3 other cell types or tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF55; MYOFERLIN; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 6.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2003..2025
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..107
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 187..314
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 334..470
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1102..1230
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1265..1389
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1513..1631
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1749..1897
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 135..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2038 AA; 231018 MW; E54D245295BD52D8 CRC64;
MLRVVVESAK GLPKKTLGVP DPITTVIFRD DKKKTKSIDK ELNPVWNEVN HADKETLCNT
SLTFTCFYYF LTSLDELPGM QQYLIFLGSA KIYLKDLASG QARSLPCKDV PLVSESGQNI
GATINLLVGY DAPANVVPNP NDPPSGETTV DAGGGGGGEE GNETLPDGSQ SGPSGTSPSG
GQSVNLRRGV ARAQSRHRLA NKPQDFQIRV RIIEARQLPG NNIKPVVKIY VCGQTHRTRI
KRGNNPFFDE IFFYNVHMLP SDLFDENISF RSVYLMWCFY VRGPFTAHCV LRKWLLLNDP
DDSSSGAKGY LKVSLFVVGT GDDPPVEKRE SNDDQDDIES NLLLPAGVTL RWATLSLKVF
RAEDIPQMDD AFVQNLKEIF GGEANKKNLV DPFLEASFAG RKLCTQIIET NANPEWNEVL
NLQVKFPSMC ERVKLTVFDW DRLTGNDAIG TTYLNLANIA SSGGEIEGNS GESEVGFLPV
FGPCYINLYG SPREFTGFPD PYEDLNLGKG EGVAYRGRIL VELSTKLDGK ADKAVDKIHS
DDVLVVQKYQ RRRKYCLCAV FHSASMIQEP GEPIQFEVSI GNYGNKLDTT CKPLASTTQY
SCAIFDGNHY YYLPWANTKP VVVVTSYWED ISHRLDSVNI ILYITHRLQS NLEEFKTAIL
AKVSDNQLAE VWLKLLNQLI EDLESFPTPE LEGHSNLTTL DIQIKKLRDR ALTSIKDGAR
RMRDEAGEIR DTLSDLESWV EKFKTLAEEP QISMPDVIIW MLRGEKRVAC SRIPAHQILY
STFSEQACGQ HCGKTQTVYL QYPMDKNKGL KVPVQIRVNM WLGLSAHEKK FSSFSEGSFS
VFAELYENQA QVFGKWGTTG LVGRHKFSDV TGKLKLKKEY FIPPRGWEWE SEWFIDPEKA
LLTEADAGHT EFMDEVFQNE TRFPGGDWKA ASEPFTDVNG EKSCNPTEFD CPPGWIWEDE
WTVDINRAVD DQGWEYGVTI PPDDKPRSWV PAEKMYHVHR RRRLIRPRKR SKVPGGAAVE
VSTAQAVAVF DLVGWEFSSL IGWKFHRNER SSDTFRRRRW RRKMAPESRL GAAAIFQLEG
ALGIDTEEKE KDSKGDATKL FGANTPTVSC SFDRSYMYHL RVYIHQARNM TSMDKDSFSD
PYAHVSFLHV SKTTEKLRAT LNPTWDQTLI FNDVEIYGDP QKIAYRPPNV VLEFYDSDQV
GKDEILGRSI CTPIVKLNSA MDQTPKLLWH PIIQKGKVAG EALVAAELIL KNKSGDSDLP
LVPPKRENIY MVPQGIRPVV QLTAVEILAW GLRNMKPYQL AAVSSPSLVV ECGGQRVESA
VIKNMKKTPN FPSSVLFIKV LLPKEEMYTP PIVLKVIDHR PFGRKPVVGQ CTISSLEQFR
CDPYVVTAEG AINCSMLTVA LMMASPHKHV SITMEETRPL LEEKETVDWW SKFYVSLGDQ
EKCGPYLKKG YDTLKIYDCE LEDVPEFKGL TDFCDTFKLQ RGKNDNGDDD PTVVGEFKGS
FKVYPFPDDP GVAPPPRQFR ELPDSGPQEC LVRIYVVRGM DLQPKDNNGS CDPYIKISLG
KNTIDDRDHY LPNTLNPVFG RMFEMTCFLP QDKDLKISVY DYDLLTRDEK VGETVIDLEN
RFLSRYNSYC GLPQSYCISG INQWRDQLKP SQILENLARL KGLSKPRTED NGNSLTFNGK
EYTLAQFESN KEIHQHLGPP YERLCLHVLR TQGLVPEHVE TRTLYSTFQP NLSQGQLQMW
VDVFPKSLGL PEPPFDITPR KPKKYFLRAV IWNTTDVTLD ETSITGERMS DIYVKGWMPG
MEEDKQKTDV HYRSLDGDGN FNWRFVFGLD YLPAEQLCLV SKKEHFWSLD KTEFRIPPKL
IVQIWDNDKF SLDDYLGTVE LDLRKLVAPA KTPEKCSLDM MDNVEIGPHK AEQNKSLFAQ
QSVRGWWPCS IEQDGKKVLG GKVEMTLEIV SEVDADERPA GKGRDEPNMN PKLDLPNRPE
TSFFWFTNPC KTMKFIVWRR FKWVFIGLII LIIVVLFIAI LLYSLPNYIS MKIVKPLS
//
