ID   A0A3Q4HYC6_NEOBR        Unreviewed;       347 AA.
AC   A0A3Q4HYC6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Interleukin-1 {ECO:0000256|RuleBase:RU003753};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000027261.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000027261.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}. Lysosome
CC       {ECO:0000256|ARBA:ARBA00004371}. Secreted, extracellular exosome
CC       {ECO:0000256|ARBA:ARBA00004550}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000256|ARBA:ARBA00010448,
CC       ECO:0000256|RuleBase:RU003753}.
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DR   AlphaFoldDB; A0A3Q4HYC6; -.
DR   STRING; 32507.ENSNBRP00000027261; -.
DR   Ensembl; ENSNBRT00000027976.1; ENSNBRP00000027261.1; ENSNBRG00000020779.1.
DR   GeneTree; ENSGT00390000016316; -.
DR   OMA; HEGKHQY; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000020779; Expressed in mesonephros.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR10078:SF30; INTERLEUKIN-1 BETA; 1.
DR   PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   SUPFAM; SSF50353; Cytokine; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
PE   3: Inferred from homology;
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Secreted {ECO:0000256|RuleBase:RU003753}.
FT   REGION          112..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   347 AA;  39017 MW;  FFC3CD219D996BF2 CRC64;
     MSQTDSLVKG GVLIAHKIHE GKHQYVVENV VKYKMENEGK LYVRKGDKLL QINGMDANDL
     TPEEVANMIA EGSPMLVTKE EDHTEQTSLT EDTLQPVSKE PTLLSFSWEM TREDDPKGTV
     VEPQEEEKET GNIEEDLCQA KTEENEMFVV EMTKTSISLV RGRGCDATGC TFNDIIMVAE
     SSTVTLVPRG GGSFRQEKLS NVLIENLATR QYLRGICSER IVYASPNPEK ITIYYYKSSG
     FRRGSSGMPV VLNLTDSNCF LMCCKQADRV LLKVETCEKQ RLKQISKSDE STLSFVFYMK
     GDSARRRRFE SALYSGWFIN VCNTDTVGVA TLDGHTVDQS FLFIIQK
//