ID   A0A3Q4HYS6_NEOBR        Unreviewed;       581 AA.
AC   A0A3Q4HYS6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Lipase maturation factor {ECO:0000256|RuleBase:RU361229};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000029235.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000029235.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Involved in the maturation of specific proteins in the
CC       endoplasmic reticulum. {ECO:0000256|RuleBase:RU361229}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU361229}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC       ECO:0000256|RuleBase:RU361229}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the lipase maturation factor family.
CC       {ECO:0000256|ARBA:ARBA00005512, ECO:0000256|RuleBase:RU361229}.
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DR   AlphaFoldDB; A0A3Q4HYS6; -.
DR   STRING; 32507.ENSNBRP00000029235; -.
DR   Ensembl; ENSNBRT00000029991.1; ENSNBRP00000029235.1; ENSNBRG00000022258.1.
DR   GeneTree; ENSGT00530000063702; -.
DR   OMA; LGTYHQN; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000022258; Expressed in zone of skin and 6 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR   InterPro; IPR009613; LMF.
DR   PANTHER; PTHR14463; LIPASE MATURATION FACTOR; 1.
DR   PANTHER; PTHR14463:SF5; LIPASE MATURATION FACTOR 2; 1.
DR   Pfam; PF06762; LMF1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU361229};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361229};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361229};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361229}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361229"
FT   TRANSMEM        78..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361229"
FT   TRANSMEM        104..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361229"
FT   TRANSMEM        131..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361229"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361229"
FT   TRANSMEM        253..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361229"
FT   TRANSMEM        300..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361229"
FT   TRANSMEM        341..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361229"
FT   TRANSMEM        383..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361229"
SQ   SEQUENCE   581 AA;  66877 MW;  B40DF4E939F694E2 CRC64;
     SKMGEVVLPR RMFLWCMAVI YLTAFVSLYV QIPGLYGNEG LLPARWQLRY SGKPLVEQLL
     SSPTLLWLGP RLGLDTHTAM ELLCLIGAAL SLAATLVEAF RDSVVFFCLW VLYLSMYEVG
     QVFLYFQWDN LLLETGFLCI LVAPLTLIRG SRGVREHDRV TFWLTRWLLF RLMFASGVVK
     LTSRCPTWWG LTALTYHYET QCIPTPLAWF AHQLPVCWQK LSMVGAFVIE IAVPFLFFSP
     LRRLRLGAFY LQVLLQVFII LSGNYNFFNL LTVTLCLSLL DDRHVYFWLH SKLWSWLCYL
     LELVVWALLI VGTIICFDLQ LDTAKKGISS RTAFTYHQFN LFLKTVTIPC IWIGVLSLTW
     EMVTSLFRCA CVSGFFKRFW GTVQWTVFAG AAASMFAVSL VPFTFIEYDS NSRLWPGVRQ
     AYEMVDRYQV VNSYGLFRRM TGVGGRPEVV IEGSSDGVTW TEIEFMYKPG NLSASPPVLT
     PHQPRLDWQM WFAALGPNTQ SPWFTSLMYR LLQGKRDVIE LIQSDVSQYP FHQQPPAYLR
     AHRYRYWFTE SKADGSVLSG SPRASLCLPA LKKLHWKHFT A
//