ID A0A3Q4HZ10_NEOBR Unreviewed; 2359 AA.
AC A0A3Q4HZ10;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Fibronectin {ECO:0000256|ARBA:ARBA00020368};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000026553.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000026553.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_006780455.1; XM_006780392.1.
DR STRING; 32507.ENSNBRP00000026553; -.
DR Ensembl; ENSNBRT00000027254.1; ENSNBRP00000026553.1; ENSNBRG00000020289.1.
DR GeneID; 102791831; -.
DR CTD; 334613; -.
DR GeneTree; ENSGT00940000155126; -.
DR OrthoDB; 5399734at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000020289; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR GO; GO:0003181; P:atrioventricular valve morphogenesis; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0003128; P:heart field specification; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR CDD; cd00061; FN1; 10.
DR CDD; cd00062; FN2; 2.
DR CDD; cd00063; FN3; 16.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 12.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR InterPro; IPR000083; Fibronectin_type1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013806; Kringle-like.
DR PANTHER; PTHR46708:SF2; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR Pfam; PF00039; fn1; 11.
DR Pfam; PF00040; fn2; 2.
DR Pfam; PF00041; fn3; 16.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00058; FN1; 12.
DR SMART; SM00059; FN2; 2.
DR SMART; SM00060; FN3; 16.
DR SUPFAM; SSF49265; Fibronectin type III; 10.
DR SUPFAM; SSF57603; FnI-like domain; 12.
DR SUPFAM; SSF57440; Kringle-like; 2.
DR PROSITE; PS01253; FN1_1; 4.
DR PROSITE; PS51091; FN1_2; 10.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 2.
DR PROSITE; PS50853; FN3; 16.
PE 4: Predicted;
KW Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2359
FT /note="Fibronectin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018633927"
FT DOMAIN 92..133
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 134..177
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 179..223
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 224..268
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 339..387
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 399..447
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 452..496
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 501..543
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 544..587
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 595..687
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 701..789
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 791..885
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 890..981
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 982..1069
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1070..1157
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1158..1250
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1251..1345
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1346..1433
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1434..1523
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1527..1617
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1618..1708
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1709..1798
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1800..1890
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1893..1983
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2077..2171
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2181..2225
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2226..2268
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2270..2310
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT REGION 1969..2024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2009..2024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 344..370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 358..385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 404..430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 418..445
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 2359 AA; 262076 MW; 83B6EB5F71D1163A CRC64;
MKGSPLTGLL LALCVSSAVH GLPKKNKRQT GQYQVYPELH DTSAINPVGC EENGRSYRVN
EQWEKPYLGS TLVCTCSGAA GIKCKTKPEV EESCYDKYND RTYQVGETYE RLHERMTWDC
TCIGSGKISC TIAHRCHDGG RSYKIGDTWQ RPHDTGAYML ECVCLGNGKG EWTCKPLGER
CYDNSLAATY AVGDTWEKPY QGWMMLDCTC MGEGNGRITC TSRNRCNDQD TRRSYRIGDT
WTRTDTSGHR LQCVCLGNGR GESKCERHSS GRARVVLTPV RQLELPAERT CRTDSGAYYY
DGQRWIKNQG SKQMLCTCLG NGVSCQEWEA RNQVYGGNSD GQPCVFPFVF MGKTYYSCTS
DGRSDGQLWC STTSDYQRDE QYSFCTEKNA IVTTRGGNSN GALCHFPFLY SGRNYTDCTT
DGRRDNMRWC GTTYDYDSEQ RFGFCPMAAH EEVCTTSDGV MRRVGDKWDK RHDVLGHMMQ
CTCLGNGRGE WNCVAYSQLL DQCIVDGLTY EVNQEFTKRH DQGYMMNCTC FGQGRGYWKC
DAIDQCQEPQ TRTFYQIGET WDKAIHGIYY RCYCYGNGIG EMRCEPQQTY QDGRRPIQVI
ITEAGKQSDS RPIQWNAPSS VQITQYILKW RVKNTRSPWR EVTIPGNINS YTISGLRPGI
TYEGQLISIQ NYGRREVTRF DFTTNLGSLE TYEGETTAPP PVLDTSESVT EITSNSFVVS
WTSADTTLSG FRVEYELSEE GSKPKVLDVP RTSTSVTISN LLPGRRYNVS VFEVPSRGQP
NLILTTSQTT APDAPTRHVV NEVGETSIRI SWSRPQAPIT GYRVVYTPSV EGSSTELTLP
ESETSVTLVD LRPGLLYNIS IYAVEEDQES EPVFVQVNTA GSPPQEVVQA PTDLQFYEVS
DTRVTITWTG PPNEVSGYRV TFSPVGSDGT DVRPLGLPVS TSAYSEITHL QPGTLYRFYV
YAISGGVESE PLVGEKATKP DAPTDVRFTE IGPDNALIVW EAPRAIVSGF RLYLSIEGSS
PIEKRIPGRV TQYLLRNLRP DTEYTATLYS DLENELSEGV TTYFTTAPQM GNAPTFSTEV
TDTSIIVTWI PVRRFSYKLS VLPSEEGESP REETSSSGRV YIDGLIPGTQ YTYSVQPIYN
GQNRGNPITR NVVTSLSPPT DLRLESNPNT GVLTAYWVAS KTPGITSYRV TSRPTNGQRG
YSLEEIIAVD QTSVVLEHLT LGMEYNISVF ATKDNVESSP VSTIVTTAIP APTNLQFGGV
GPDHIRVTWS VPRIATPNDI SRFVIRYHPV STDNDIKEVN VGGATNTYLL QNLQPNTDYR
ISVVCVYGER ESRPATGTQK TTLDSPTGLD FSDIRTDSFT VHWQAPQARI TGYRIRYQKT
SGGHAKDERL PPTRTHYTLT GLSPETEYMI YVYAVSSSQE SQPLTGTQAT ISDSPTDLVV
TRSTPTTVTI RWDAPSISVR NYRITYAGRS GETPREINVP GTQTTATITE LNPGTEYTIT
VYAVSGRGDN PATSVPVYIT HRTDIEAPPD MRVADISDNA ITVRWSPARG PIRGYRVTSI
PKNGVGPSYS EDLAPDQTEV TFTGLMPTAE YLVSVYALGN NGQPSSPLIE NAVTAMDRPK
ELTFSDIDST SMRISWDSPD GAVTSYRVLY TSAEEGEKEL HPAPRGDQDS VVLRNLRPGT
EYTVKVIALH DRTPSSPLVG TQATVIPAPT YLAISEVSPS SFTVSWRAPD ARLTGYRVVV
SPKNINSPHR EMNVAPDTTR VVVPGLMVAT TYQVQVYALK NTVTSRPAEA EATTLQALSA
PRRVRVMKVM DSSFTLTWRS KLEPFTGFLI EAIPQSGSYP TITKTIPSEA YTYTLTGLRP
NTIYNVNMYT LSGNTRSDPF TLRIQTAAPL VQAPTNLQFT SVTPYSISFT WQPPPTQITG
YYVTYEESGG RPQELFPRPH AGQNYATISD LRPDTEYIIK IIAIQNTQRS TPLVGRSRTP
QDPLLPLPLP QPNRPGNGRL DVPESLDNNV QLVGPNNQNG FGDQSQHVEY TEYNNNGDNG
YNRNPLSPYG QVREPLVFVP LPDAEGRRKP IVKLNMPVGS ILFNETSVPL EAQTQTTVSW
KPYRQSNAYL VSCRPITQLN EKMFQVRLPG TATTATLLGL TPGADYNVIV EALLGALKHK
ILEQTVTAGN TITEGDSSNK DTCYDAFTAT HHNVGAEWER MSETGFKLLC RCLGLGSGHF
RCDSSKWCHD NGNNYRIGEK WDRRSENGNL MSCTCLGNGK GEFKCEPHES TCYDDGKTYR
VGNQWQKEYL GSICTCTCFG GQQGWRCENC RRPGGDVDVG LLQPIRYGDN TLRKNIHCPI
ECLRPELLAD AHVPHNPRE
//
