ID A0A3Q4HZN4_NEOBR Unreviewed; 530 AA.
AC A0A3Q4HZN4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Interleukin-18 receptor 1-like {ECO:0000313|Ensembl:ENSNBRP00000026813.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000026813.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000026813.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR AlphaFoldDB; A0A3Q4HZN4; -.
DR STRING; 32507.ENSNBRP00000026813; -.
DR Ensembl; ENSNBRT00000027520.1; ENSNBRP00000026813.1; ENSNBRG00000020465.1.
DR GeneTree; ENSGT01090000259985; -.
DR OMA; THFREHD; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000020465; Expressed in mesonephros.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF6; INTERLEUKIN-18 RECEPTOR 1; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01536; INTRLKN1R12F.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 317..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..199
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 216..308
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 363..509
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 530 AA; 59628 MW; FF416D14B25D3BFF CRC64;
VIILINDTLK LFHFAGVCPQ IPEEIWVKEG EIVAKFFKEC DHNETLWRSF TKQGMHLHNN
TPAAEHRQMG VMVQQGIFVI LSASEKNEGN YSCSLKNSSR QSWIILKVYT GQSRDSEQMN
QISKVCYTEE YCQLYCPEKN VRFNTLNITR SGITWHKEGG SSPKDGYFPS VKKEDSGNYT
CTRSYLYDGQ IYNMTSTVKL DVQPNKITKK AVIISPENKQ VFEIDLGSTV MIDCKAVMMS
DTDGLVWLSG NSFVETDTSL PVFYNDTHTE EISMTISLIF RKVSEEDLSK NYTCKLQSAY
QTSFVTITLK QKASRSYTSL GVCFVIIVVV TFVTVVTYVK FKIDITLFLR DTLKWSGSIS
DGKCYDAFVM CYKCDTAGGL NPSDKRWLES VLEEKFGYSL CLYDRDVLPG KAIADAVLDC
VEQSRAVVLV PVSPDPDPES GLLSAIHEAL VERQTRLVFI TTETSMASKS DSFPEALQLL
SKAGNCVTWK GISSMPTSSS FWKQLRYYLP APQQAPTVEL LPQTIQDVTS
//
