ID A0A3Q4I216_NEOBR Unreviewed; 798 AA.
AC A0A3Q4I216;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Signal-induced proliferation-associated 1 like 2 {ECO:0000313|Ensembl:ENSNBRP00000028756.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000028756.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000028756.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q4I216; -.
DR Ensembl; ENSNBRT00000029507.1; ENSNBRP00000028756.1; ENSNBRG00000021821.1.
DR GeneTree; ENSGT00940000157388; -.
DR OMA; CHESTSW; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000021821; Expressed in zone of skin and 8 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.1120.160; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF7; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 340..527
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 667..743
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 798 AA; 89487 MW; 8CF63FCBA76C5633 CRC64;
MGPPVVQGAP VVPKMGVRAR MSDLSQRRDA QEGLNSSFLS QPPHSNKSLD PQPRSETTFP
VRPSPSTSRS LARMKRSNSE VTISDAGAED PAAINPNTDA SLRRNAISYK CFSHYDSQSV
LFDFSSGFVP QADLQHRRND STSGCDVFDA LSPDEREKNN FLVSSCPFFH NEIGGEMERR
LGLTRANTST CGAAADTSFS EPPLSTRRTN ASISVLEFSG GTRAFDQNLM NNHDIEHIDL
GARYYLKYFY NQGKSNHQNY FGIDENFGPV SLSLRLIQSC PLFQLSTLRG SITEDSIPSS
SKHGTSRRLP LKDVLEFVVP QLSIHSLRLA ADSPRVPELL LQLDQQELRF QRKVGVLFCR
AGQSTEEDNS DSGSPALDQM VFDDSTGRQS VFTTFREFKL MFHVSTASSP QQVILLFDLV
LCTVLYQRPG SLRFLPQNIC SHSQHVFIIV RVHRPCSQHT CYSIAVSRRR DIPFFGPLIP
PGWMFSASPE FRNFLLTKII NAENAAHRSE TFVTIRARHR QEHLKELVES FSTSVLVDSS
SSIKFSFISL VVKKKERSAP RPHAYLNTAG ALTWSVTAKD FSCSFDVPCQ LAISSEFVVL
VEEASRQVVF HCYCRDVIGW NAGHKGIKLF YEHGDCVMLS TRERGWEDSR EIAQRLQLVT
HGGPAVDMIL RRNRHGQLGF HVNFEGVVAD VETNSFAWKE GLRPGCRIME ICAVAIVTLS
HKQMIELLRT SMTVSVVVIL PHRDGTPRRS RDGLFELYFN GFRVKHNPMP GPRHHVSRIP
GDLSLNQVCM ILWALTDT
//
