ID   A0A3Q4I2I4_NEOBR        Unreviewed;       529 AA.
AC   A0A3Q4I2I4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 4-like {ECO:0000313|Ensembl:ENSNBRP00000024327.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000024327.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000024327.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC
CC       1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   AlphaFoldDB; A0A3Q4I2I4; -.
DR   STRING; 32507.ENSNBRP00000024327; -.
DR   Ensembl; ENSNBRT00000024965.1; ENSNBRP00000024327.1; ENSNBRG00000018606.1.
DR   GeneTree; ENSGT01080000257365; -.
DR   OMA; IQHTIDS; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000018606; Expressed in camera-type eye and 3 other cell types or tissues.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767:SF100; G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4-LIKE; 1.
DR   PANTHER; PTHR11767; INWARD RECTIFIER POTASSIUM CHANNEL; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU003822};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU003822};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU003822};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW   ECO:0000256|RuleBase:RU003822};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003822};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003822};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW   ECO:0000256|RuleBase:RU003822}.
FT   TRANSMEM        176..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        261..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          142..289
FT                   /note="Potassium channel inwardly rectifying transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   DOMAIN          296..465
FT                   /note="Inward rectifier potassium channel C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
FT   REGION          487..529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        514..529
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   529 AA;  60301 MW;  BAF621A18CF31B31 CRC64;
     MTLPLPDIMP GTFSDLTTAR QRHKSTTDFP HQGNISLLPS YTHCLIDREQ DLLRRCSLRE
     TKSLSRYPRH ALSVPEIGCI SPLHVITHSP LHSTPLSPAK SNISSPAREM EKLAKARSKL
     LESETNQTPT IAPETREQLR YVAKDGKCRV NLCHISERGR FLSDIFTSFV DLQYRWFLFV
     FMMCYIVTWF FFAVLYFLNA FFRGDLEKEK PLTTPEENLI DRAPCYLGVD DFISALLFSV
     ETQRTIGYGS RTVSPSCHEG VVLVMTQCIV GSMIDALMVG CMFVKISRPK KRAETLLFSR
     TCVIANRDDQ LCLMFRLGDL RESHMVDAKV RAKLIKSRQT AEGEFLPLEQ TEINLGYETG
     SDRLFLVEPQ VIQHNIDCDS PLWELGPEQL RRQQFEIIVI LEGIVEATGM MCQAKTSYIE
     TEIEWGARFE PCMMLEKGSF RVDLRRFHTT YKVPLPNCSA SQAHQLMALA DCKVQNHRTS
     QNWESWAEGM TEEDKDKQPS HGGFTIANIQ EERASEGNES EEGTEKSTP
//