ID A0A3Q4I3P6_NEOBR Unreviewed; 1013 AA.
AC A0A3Q4I3P6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Nardilysin-like {ECO:0000313|Ensembl:ENSNBRP00000029371.1};
GN Name=NRDC {ECO:0000313|Ensembl:ENSNBRP00000029371.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000029371.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000029371.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR AlphaFoldDB; A0A3Q4I3P6; -.
DR Ensembl; ENSNBRT00000030128.1; ENSNBRP00000029371.1; ENSNBRG00000021922.1.
DR GeneTree; ENSGT00940000155026; -.
DR OMA; INQVMEH; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000021922; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 87..213
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 240..410
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 416..696
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 701..882
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..52
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 116114 MW; E75EDF7C7440D64B CRC64;
LISDYSGLTE DGESDEDEEE EEEEDDDDDE SEDGSEDGSE EDDEDEGVDD EDDYNEGKKK
KGNAEKQVQE TRDAMPDSDM PRYPVFQSAA ALCVGVGSFS DPSDLPGLAH FLEHMVFMGS
EKYPSENGFD AFLKKHGGSD NASTDCERTI FQFDIQRKNF KEALDRWAQF FICPLMIRDA
IDREVEAVDS EYQLAKPSDS HRKEMLFGSL AKPGHPMGKF CWGNAETLKQ EPKRMKINVY
KRLRAFWKKY YSAHYMTLAV HRFDYVSELG LPKPDFSDML DPFDTTAFSK LYRVVPVGKV
HALNITWALP PQEKYYRVKP LHYISWLIGH EGTGSILSVL RKKCWAVALF GGNSETGFDQ
NTTYSIFSIS ITLTDEGFQN FYKVTRLVFQ YLKMLQTLGP QQRIYEEIQR IEANEFHYQE
QIDPIEYVED ICENMQLFPK EDFLTGDQLM FEFNPGVISA ALSLLTPEKA NLMLLSPEHE
GQCPLREKWF GTQYNMEDIQ QEWMEQWTGN LELNADLHLP AENKFIATDF TLKPSDCPDT
EFPVRIADSD RGCLWYKKDN KFKIPRAYIR FHLISPVIQQ SANVVLFDLL VNILGHNLAE
PAYEAEVAQL EYKLVAGEHG LVIKVKGFNH KLPLLFHLII DHLADFSASP DVFSMFAEQL
KKTYFNILIK PEKLSKDVRL LILEHSRWSM VDKYQALTAG LTTEELTEFS RSFRAELFAE
GLVQGNFSSA ESVQFLQYVT DKLQFSKLTA EVPVMFRVVE LPQKHHICKV KSLNKGDANS
EVTVYYQSGP KALREHTLME LLVMHMEEPC FDFLRTKETL GYHVYPTCRN TSGILGFSVT
VETQATKFNT ELVELKIEEF LTSFGEKLNA LTEEAFNTQV TALVKLKECE DTHLGEEVDR
NWAEVVTQQY VFDRLNREIE ALKQMTRDEL VSWFKEHRGQ SSRKLSVHVS NAFVGEKQEE
KGKDEDLRSS AYGEVSKLSF LPASPKVEGA IAIVDIPAFT EGLPLFPYHK ILK
//