GenomeNet

Database: UniProt
Entry: A0A3Q4I3P6_NEOBR
LinkDB: A0A3Q4I3P6_NEOBR
Original site: A0A3Q4I3P6_NEOBR 
ID   A0A3Q4I3P6_NEOBR        Unreviewed;      1013 AA.
AC   A0A3Q4I3P6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Nardilysin-like {ECO:0000313|Ensembl:ENSNBRP00000029371.1};
GN   Name=NRDC {ECO:0000313|Ensembl:ENSNBRP00000029371.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000029371.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000029371.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q4I3P6; -.
DR   Ensembl; ENSNBRT00000030128.1; ENSNBRP00000029371.1; ENSNBRG00000021922.1.
DR   GeneTree; ENSGT00940000155026; -.
DR   OMA; INQVMEH; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000021922; Expressed in muscle tissue and 6 other cell types or tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          87..213
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          240..410
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          416..696
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          701..882
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..52
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1013 AA;  116114 MW;  E75EDF7C7440D64B CRC64;
     LISDYSGLTE DGESDEDEEE EEEEDDDDDE SEDGSEDGSE EDDEDEGVDD EDDYNEGKKK
     KGNAEKQVQE TRDAMPDSDM PRYPVFQSAA ALCVGVGSFS DPSDLPGLAH FLEHMVFMGS
     EKYPSENGFD AFLKKHGGSD NASTDCERTI FQFDIQRKNF KEALDRWAQF FICPLMIRDA
     IDREVEAVDS EYQLAKPSDS HRKEMLFGSL AKPGHPMGKF CWGNAETLKQ EPKRMKINVY
     KRLRAFWKKY YSAHYMTLAV HRFDYVSELG LPKPDFSDML DPFDTTAFSK LYRVVPVGKV
     HALNITWALP PQEKYYRVKP LHYISWLIGH EGTGSILSVL RKKCWAVALF GGNSETGFDQ
     NTTYSIFSIS ITLTDEGFQN FYKVTRLVFQ YLKMLQTLGP QQRIYEEIQR IEANEFHYQE
     QIDPIEYVED ICENMQLFPK EDFLTGDQLM FEFNPGVISA ALSLLTPEKA NLMLLSPEHE
     GQCPLREKWF GTQYNMEDIQ QEWMEQWTGN LELNADLHLP AENKFIATDF TLKPSDCPDT
     EFPVRIADSD RGCLWYKKDN KFKIPRAYIR FHLISPVIQQ SANVVLFDLL VNILGHNLAE
     PAYEAEVAQL EYKLVAGEHG LVIKVKGFNH KLPLLFHLII DHLADFSASP DVFSMFAEQL
     KKTYFNILIK PEKLSKDVRL LILEHSRWSM VDKYQALTAG LTTEELTEFS RSFRAELFAE
     GLVQGNFSSA ESVQFLQYVT DKLQFSKLTA EVPVMFRVVE LPQKHHICKV KSLNKGDANS
     EVTVYYQSGP KALREHTLME LLVMHMEEPC FDFLRTKETL GYHVYPTCRN TSGILGFSVT
     VETQATKFNT ELVELKIEEF LTSFGEKLNA LTEEAFNTQV TALVKLKECE DTHLGEEVDR
     NWAEVVTQQY VFDRLNREIE ALKQMTRDEL VSWFKEHRGQ SSRKLSVHVS NAFVGEKQEE
     KGKDEDLRSS AYGEVSKLSF LPASPKVEGA IAIVDIPAFT EGLPLFPYHK ILK
//
DBGET integrated database retrieval system