ID A0A3Q4I4A5_NEOBR Unreviewed; 1018 AA.
AC A0A3Q4I4A5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000028608.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000028608.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; A0A3Q4I4A5; -.
DR STRING; 32507.ENSNBRP00000028608; -.
DR Ensembl; ENSNBRT00000029352.1; ENSNBRP00000028608.1; ENSNBRG00000021760.1.
DR GeneTree; ENSGT00940000158097; -.
DR OMA; HDAIGKD; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000021760; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd16726; RING-HC_MIB2_rpt1; 1.
DR CDD; cd02339; ZZ_Mind_bomb; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR042056; MIB1/2_ZZ.
DR InterPro; IPR010606; Mib_Herc2.
DR InterPro; IPR037252; Mib_Herc2_sf.
DR InterPro; IPR040847; SH3_15.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR24202; E3 UBIQUITIN-PROTEIN LIGASE MIB2; 1.
DR PANTHER; PTHR24202:SF4; E3 UBIQUITIN-PROTEIN LIGASE MIB2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF06701; MIB_HERC2; 2.
DR Pfam; PF18346; SH3_15; 2.
DR Pfam; PF13920; zf-C3HC4_3; 2.
DR Pfam; PF00569; ZZ; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 9.
DR SMART; SM00184; RING; 2.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF159034; Mib/herc2 domain-like; 2.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS51416; MIB_HERC2; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 77..157
FT /note="MIB/HERC2"
FT /evidence="ECO:0000259|PROSITE:PS51416"
FT DOMAIN 163..215
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 226..304
FT /note="MIB/HERC2"
FT /evidence="ECO:0000259|PROSITE:PS51416"
FT REPEAT 541..573
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 574..606
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 607..639
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 708..732
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 742..774
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 974..1007
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 43..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1018 AA; 112389 MW; D148C8C2ABA3DF67 CRC64;
MYQLLSVLGA FYCDCSFNAF YPFFPSVTPD LFPETTLVPS LPAVPSARAG SAPQKPRRRS
SSGRDSVARP QTLPSACRPG PKRGSMEVGM RVVRGLDWKW GNQDDGEGHV GTVVEIGRQG
STTTPDKTVV VQWDSGTRTN YRTGYQGAYD LLLYDNAQIG VRHSNIICDS CKKHGIMGMR
WKCKVCFDYD LCTQCYMNNK HDLSHAFERY ETAHSQPVSL APRQNLPRII LKGIFQGVKV
VRGPDWDWGN QDGGEGKVGK VVDIRGWDNE SGRSVASVTW SNGTTNVYRM GHKGKVDLKY
VTDGQGGFYY KDHLPKLGEH AELQRQESAD GHSFQQGDKV KCLLEVDILR QMQEGHGGWN
PKMAEYICRI GTVHRITDRG DVRVQYSNNI RWTFHPGALT KVNTFGVGEL VRVLEDMESV
KRLQAGHGEW TDSMTPVLGQ VGKVLKVYAD GDLRVAFGGQ TWTFNPACLS AQPVEVDANL
MTAENPNESG STVISVLEKL LSQSTEQDNP SRLVIEAAHG SASKVRELVQ KYPDKVDIKN
QGKTALQVAA HQGHMEVVKA LLQANSSVEV KDEDGDTALH YTAFGNQAEI ARLLLSKGAN
VNLLNNSMCT ALHIAVNKGF TDVVRVLTEH SADVNLQDSY GDTPLHDAIA KDFRNIIEIL
SMVPNIDFTQ QNHRGFNLLH HAALKGNKLA TEKILARARQ LVDVKKEDGF SALHLAALNN
HKDVAEILIK EGRCDINIRN NRNQTPLQLA VTQGHTELVQ LLVDEGADVN MEDEDGDTAM
HVALLRPQLA NVMLSPSVGL LGSTELSVGT AVACFLAMEG ADISYANHKG KSPLDLVADS
TMLQLIKSFS EKLQRLQAIT CGQGLSSASL RRVHTTPNTM TNLVLPTPPG PSECLICSEL
ALLVLFCPCQ HSVACEECAH RMKKCIKCQV TITKKIRQDQ TEVDCSPGTE NSEQHNLLEQ
LQSRYRQMEE RMTCPICIDN HIKLVFQCGH ASCIDCSAAL KTCPICRQTI RERIQLFV
//
