ID A0A3Q4I4N9_NEOBR Unreviewed; 1822 AA.
AC A0A3Q4I4N9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Tuberin-like {ECO:0000313|Ensembl:ENSNBRP00000031520.1};
GN Name=TSC2 {ECO:0000313|Ensembl:ENSNBRP00000031520.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000031520.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000031520.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_006790788.1; XM_006790725.1.
DR Ensembl; ENSNBRT00000032316.1; ENSNBRP00000031520.1; ENSNBRG00000023922.1.
DR GeneID; 102777459; -.
DR CTD; 7249; -.
DR GeneTree; ENSGT00950000183139; -.
DR OrthoDB; 20915at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000023922; Expressed in blood and 9 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR003913; Tuberin.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR PRINTS; PR01431; TUBERIN.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT REPEAT 489..527
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1548..1775
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1054..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1387..1509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1773..1806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1485..1502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1822 AA; 201236 MW; F8B65A8568833818 CRC64;
MNKQPSKESL KDKVKGIFGL GTQRPPNKQS DTKPSEFIIT ADIIKELHPD CGLSNRVRTM
NHICELAKMK KFEEHAVEAV WKNVEDMLTP EQPPEARHAV LQLLRAIIQG QGERLGPLRA
YFFKVIRDYQ PCNEDLSDRL EVFKALTENG KDITYLEEDI ARFVLLWMDI GLTSDFLHVL
VNLVKFNSCY LDQNVSIMVQ KICLLCNRTT SSTDIEVALQ VLDAVVCYNC LPSDSLTVFI
ITLCRTVNVK EFCESCWKLM RKVLGTHLGH SAIYTMCRIM EERVYMEDAP LLRGAVFFVG
MALWGAHRLP ALKNTPTLVL PSFYKAMSCA NEVVSYEIVL SITRLIKKYG KELQVVTWDI
LLGIIERLLQ QIQTIGSAEL KAIVYELLTT VEELYEQNGY HGSTEKFFSL VEKCADKRPD
ASVLTLISYR AQSIQPAKEG WIQSLHRLME KFFRNETRSV IRIKVLHILS FVLSTNRQLY
EDELIEMVVI PQLSGIAEDR DLAVRKQATQ LLVDLAEGCN THHFTSLLDI IERVSSRSLV
YSGPLEVTER DPTAESPMED VRTAILGLLE ILQSKLYSLP ASHASRVYEL LISHLQLHYK
NKYCSTIAST IRLQVFDFFL MMRADSLHRL GVPNKDGVMR FSPYCYCDIG EPEKRVGEKK
PAGSTSPPAG SPAPPAAPPT SAASTRSAYL PYSPAFSVLL QCLKMETDWK VLKLVLDKLP
WMLQYKVLLL TSPCNLDQLC STLCCMVTDR LISERLKKTP EGFSRTDVQL AVIPVLTAIT
SYHNYLEQSR QRELVQCLET GLIYRCAKQC VVALTMCTVE MPDIMIKLLP ALIVKLTHIS
ATVAMASPML EFLSTLVRLP HLYANFVAEQ YVSVFAISLP YTNPSKFNQY IVSLAHHVIA
MWFIRCRLPF RKDFVQYITK GLRSNALLPF DDSHEQSPFR ARSTSLNERP KRMHTSTTTC
SLGSADENAV TQADEGLKTV HLELTETCLD MMARYVFSNF SALPKRSPIA EFLLAGGRSM
TWLVGNKLVT ITTSGGVRTQ ALLGLDMADR LGGGGGELTR SDPSLHTRMT KEAPAKLESQ
SSQQHNRAAR IRVRSMSGGH ALRAGPAQSL SPLVSPSEGE LTAPLSPSSG PALDSLGPSS
STSATPSAPP TLKDNPTLAE FAPMLTQGWA EIFIRRPSGN TSWLMCLENP PSPFSSELGN
MPLQELSSVL MAMEGVKEPP TQTASAPAST AVPAPAPVSE PLTQTHSSVG GKANLIQRSN
TDSVVVLEEG SGIATAQTPP EWLGSAEFEP MLSDPIFIAA DKFTKTPPEI LSRSSSTSSQ
DDEKSTLEEV SEGAIPIDQP PFGPSTPGSQ GPDLPFQTHT QSQGHGLNKS SSSPELQTLP
EAFAKAAMES ESAMVDTSRP RAPSDGMPQP QQPQFVKEKV EGNTGVDTNV AGGPSPAGEG
QAVSSSQSGG AGMRLSFPPA PVQSAPISPS GGHRPRGHTI SVSAPSSRRE RRAERDAYHS
RPGPSNAEKI SGLSPSFVFL QLYHSPFFGN EANKPLLLPK TQVIDRAVKV LDQMPPYDTH
KIGVVFVGAG QVNNEVAILS NEYGSNRYAS FLTGLGKLIH LKDCDPDQIF LGGLDQYGDD
GEFTYCWHDD IMQAIFHIAT LMPNRESDKG CCNKKRHIGN DFVMVVYNDS GEEYKLGTIK
GQFNFVEVII KPLDYECNLV TLQCRKDLEG LVDTTVAKIV SDRNLPLLVR QMALHANMAS
LVHQYRANPS DAYASKWLAR LRHIKRIRTR AQEAIQSRST PGISLTQGQS KPLSQSSAPT
NVEATGQRKR LVSTVDDFTD FV
//
