ID A0A3Q4I5A1_NEOBR Unreviewed; 710 AA.
AC A0A3Q4I5A1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transducin-like enhancer protein 4-like {ECO:0000313|Ensembl:ENSNBRP00000028988.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000028988.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000028988.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR AlphaFoldDB; A0A3Q4I5A1; -.
DR STRING; 32507.ENSNBRP00000028988; -.
DR Ensembl; ENSNBRT00000029744.1; ENSNBRP00000028988.1; ENSNBRG00000022080.1.
DR GeneTree; ENSGT01030000234519; -.
DR OMA; RXSPSAS; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000022080; Expressed in brain.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF31; TRANSDUCIN-LIKE ENHANCER PROTEIN 4; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 17..131
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 510..551
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 552..593
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 136..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 25..52
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 228..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 76556 MW; CA29D77F19BD3B8A CRC64;
MYPPARHPVP HQPGQPFKFT VTESCDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY
VMVRQLTSCV AISILLAEIV KRLNAICAQV IPFLSQEHQQ QVVQAVERAK QVTMAELNAI
IGQQQLQAQH LSHGHAIPVP LTPHPAGLQP PLPPGASTAS LLALSSALSH QLPLKDERKH
HDNNSEHTRG EVCSVCADPV SPRGSPAHSP RENGLDKSRL LKKDPPLSPS SIASSSSTPS
SKSKDINMNE KSTTPVSKSS TPTSRSEAPT PSSASTTGLR SAPSKSSGVE ALSKCSPGLR
TPLAVPCSYP GPFGMVPHPG MNGELSGTGA AYTGLHNISP QMSAVAAAAV AAYGRTQVVG
FDPHHHIRVP GLPPNLSGIP GGKPAYSFHV SADGQMQPVP FPPDALIGPG IPRHARQINT
LTHGEVVCAV TISNPTRHVY TGGKGCVKVW DISHPGNKTP VSQLDCLNRD NYIRSCRLLP
DGRTLIVGGE ASTLSIWDLA TPTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV
WDLNNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI
FSLGYCPTGE WLAVGMENSN VEVLHVTKPD KYQLHLHESC VLSLRFAHCG KWFVSTGKDN
LLNAWRTPYG ASIFQSKESS SVLSCDISID DKYIVTGSGD KKATVYEVIY
//
