ID   A0A3Q4I6Y4_NEOBR        Unreviewed;       526 AA.
AC   A0A3Q4I6Y4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Acid-sensing ion channel 4-like {ECO:0000313|Ensembl:ENSNBRP00000026087.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000026087.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000026087.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBUNIT: Homotrimer or heterotrimer with other ASIC proteins.
CC       {ECO:0000256|ARBA:ARBA00038726}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. ASIC4 subfamily. {ECO:0000256|ARBA:ARBA00038140}.
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DR   AlphaFoldDB; A0A3Q4I6Y4; -.
DR   STRING; 32507.ENSNBRP00000026087; -.
DR   Ensembl; ENSNBRT00000026778.1; ENSNBRP00000026087.1; ENSNBRG00000019966.1.
DR   GeneTree; ENSGT00940000159052; -.
DR   OMA; IHEYCDY; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000019966; Expressed in brain.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   PANTHER; PTHR11690:SF13; ACID-SENSING ION CHANNEL 4; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|RuleBase:RU000679}.
SQ   SEQUENCE   526 AA;  59291 MW;  64CBAD4D839C472E CRC64;
     MPIEFVCKIK FAEEDEKQKS KQDGDKESLI EESCAPPAKD LAGFANSCSL HGINHIFVSG
     RLGIRQTLWA LAFLTSLALF LYQAAKCAIS YLEHPHVTAL NEEATPEMVF PAVTICNINR
     FRFSALTDAD IYHLANLTGL PPKNRDGHKP TDLMYPAPDM QDIFNRTGHQ LEEMLMSCNF
     SGQNCSAEDF TVVYTRYGKC YTFNGNKTTS RKTKQGGMGN GLEIMLDIQQ DEYLPIWRET
     NETSLEAGIR VQIHSQDEPP YIHQLGFGVS PGFQTFVSCQ EQRLTYLPQP WGNCRSTSKE
     KFPGYDTYSI SACRLLCETN EVLRVCNCRM VHMPGTADIC PPSKINCVDK ALAQLQKNSG
     DICPCETPCN LTRYGKELSM VKIPSKGSAR YLSRKYDKSE DYIRDNFLVL DIFFEALNYE
     TIEQKKAYDV AGLLGDIGGQ MGLFIGASIL TVLEILDYIY EVQCACKSAH ISQSQYETRP
     VIKHRLQRLL RPQKEEKKNK QQASTVATVG LEEMKAKVQH MVQCNK
//