ID A0A3Q4I6Z9_NEOBR Unreviewed; 256 AA.
AC A0A3Q4I6Z9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Stanniocalcin {ECO:0000256|ARBA:ARBA00017831, ECO:0000256|RuleBase:RU369112};
DE Short=STC {ECO:0000256|RuleBase:RU369112};
DE AltName: Full=Corpuscles of Stannius protein {ECO:0000256|RuleBase:RU369112};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000029743.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000029743.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Its primary function is the prevention of hypercalcemia. Upon
CC release into the circulation, it lowers calcium transport by the gills,
CC thereby reducing its rate of influx from the environment into the
CC extracellular compartment. STC also stimulates phosphate reabsorption
CC by renal proximal tubules. The consequence of this action is increased
CC levels of plasma phosphate, which combines with excess calcium and
CC promotes its disposal into bone and scales.
CC {ECO:0000256|ARBA:ARBA00003962, ECO:0000256|RuleBase:RU369112}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748,
CC ECO:0000256|RuleBase:RU369112}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU369112}.
CC -!- SIMILARITY: Belongs to the stanniocalcin family.
CC {ECO:0000256|ARBA:ARBA00008693, ECO:0000256|RuleBase:RU369112}.
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DR AlphaFoldDB; A0A3Q4I6Z9; -.
DR STRING; 32507.ENSNBRP00000029743; -.
DR Ensembl; ENSNBRT00000030506.1; ENSNBRP00000029743.1; ENSNBRG00000022644.1.
DR GeneTree; ENSGT00390000005989; -.
DR OMA; CAERTMP; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000022644; Expressed in heart and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR InterPro; IPR004978; Stanniocalcin.
DR PANTHER; PTHR11245; STANNIOCALCIN; 1.
DR PANTHER; PTHR11245:SF1; STANNIOCALCIN-1; 1.
DR Pfam; PF03298; Stanniocalcin; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU369112};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU369112};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..256
FT /note="Stanniocalcin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018717482"
FT REGION 234..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 256 AA; 28057 MW; A2C839C5B4F33DC8 CRC64;
MPLRTGLFLL LVLNASAYEV DQNESYSPRR ARFSANSPTD VARCLSSALQ VGCGAFACLE
NSTCDTDGMH DICKSFLYSA AKFDTQGKAF VKESLKCIAN GITSKAFLTI RRCSAFQRMI
SEVQEECYSK LDICTVARSN PDAIGEVAQL PSHFPNRFYG KLLQSLMDCD EDTVERVRTS
MVSRLGPEMT MLIQLLQNKP CPSTAVAAAA AIPTGAESRG SWRLSMGPHV YKIQPNLRNR
DSASHFGKKR SASDSS
//
