ID A0A3Q4ICD5_NEOBR Unreviewed; 2098 AA.
AC A0A3Q4ICD5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000028657.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000028657.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR STRING; 32507.ENSNBRP00000028657; -.
DR Ensembl; ENSNBRT00000029405.1; ENSNBRP00000028657.1; ENSNBRG00000021637.1.
DR GeneTree; ENSGT00940000167492; -.
DR OMA; KRTMAGN; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000021637; Expressed in testis.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 13.
DR CDD; cd14616; R-PTPc-Q; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF1; PHOSPHATIDYLINOSITOL PHOSPHATASE PTPRQ; 1.
DR Pfam; PF00041; fn3; 11.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 15.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 9.
DR PROSITE; PS50853; FN3; 14.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT DOMAIN 153..241
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 244..364
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 365..461
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 466..555
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 560..649
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 654..741
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 746..852
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 860..962
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 967..1054
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1059..1152
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1156..1244
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1205..1331
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1248..1367
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1372..1466
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1471..1569
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1803..2058
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1976..2049
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 2098 AA; 231856 MW; F08C026202A3F23B CRC64;
SSSVPGPPLI LEGEAVGSNA PGLVTNLTAY AHNHTFVVLT WFLPHRINGL ITKFAVKARF
ARTGQIVRLL EVNAVDIMTV ALPHCNVLCF SFTLLLNCAF IAKSSWNVPI SVGVDQLRPY
IAYLFEVSAF TSEGEGQIAS TMVRMPESAP EDPPQNFSVF SMTSRSFSAS WNPPSITTGK
FSYVLYLYGP TGFIYENSTG DTRFAFTGLK PYTRYIVAVR AKAAGEVGPA AKGDIVTPAE
APSAVQHLMA IAEDSVSIRV SWKSPAQPNG PIIQYRLLVL VEETLVQNIT MTAVSQMILS
LPLYASSLKN TVKDIQEVMD VLSEELSYLV SDLVPFTEYT FRVTASTTVG EGPAADITEK
TREQVPSSVL EVSYQNISST SILVSWTPPI NPNGRITHYT VYGLKLPSNQ GLKWVTNTTS
ILITGNLDKY TPYKLRVAAS TVVGESSLSE EDDIFVFTLE DEPDSPPVNL TVVNTTPSTA
TIAWSAPEKA NGAIQQYEVL YENESYSALV NTSSNKVTLF SLKPFSFYNV SVSAYTRYGN
GNQTSDTLYL LSGEDVPGSP PYGLSYESVS PSEVNVTWMP PLLPNGVIIH YSLEIWNSSH
YLNLTSRTNY IHITHLRKYA HYRVVVQAHT GVGAGNYSSE PLNITTLEDA PGTPPQFLHA
RKLSDFEVEL SWQPPLEANS DILYYVVRVW NETTDLWQNV TKTSVVINVD SESRYNASVS
SWTKLGDGGV LIYISFTTTD AEPFDPPQNV TIVNADASSV TLMWYPPTEP NGIIVHYTIY
YSFNNIPYTS FSPQTVPVSD LYSHTSPNSR LSYTLTGLIG GNNYTLWMAS STVQGDGGVH
SELIIVTLFF LSHSLVPGDS VQNLTAQIFS STVIIVSWDP PLEPNGRPYY LLTLQEAGIV
PNISNQKAPA VNKTIKHTTT DNIFLFTKLR KYFPYVLTVT PATTAGPAYN HTRTMYLRTD
DDIPSSAPLL VSTRNLSSSS FGVVWQRPLE ANGEITEYTL ILVGPEGTDT THTPNTSFVF
TNLLPYTAYN LTITAATRKG SGPSLLLQLH SDESGPTSPP RNLTIYNHTA VSVWLSWEPP
LEPNGVVIKY GFRIQDLITQ TVTHRNSSGS STTEYLAGFK PHSSYEISVN SFTRVGHGNQ
FSSPVSFTTN ESVSDAVGNL SCSGLSWDSI LLSWEIPANP NGQIIFYEIQ LEVDQQSYKH
EAHTPEYTVT GLSPDQEYAL SVAAVNSAGP GDRLNCTAST LSESVPAAPR FLTISQVTPN
NVTLQWAPPH SVPGLLKEYH IIAQLISANC ESSISVKAQS TPKDDLALHC IEHNVTVSIN
ASDAEQEQSF TIHPVAKYRY YRFKVAAVTN AGVGDYTQWK YKRTMAGNPD APPRDLKVTS
TSNSFHIAWD APAVLSGLTS YLVQVDGPGV NISIVRTPGE LMTIVVTNLT AFSRYSVTIT
AFTGDLEHAS SDGKAIGPIY FQTKEEEPKD PPKNVTVSVI PEEVRAVKLT FNPPEEPNGN
ITEYIVYIFE KDQLVRNISL NIIQKENNTM DAVIEGLKGG RTYSLQISAK NGAGKSPLSS
RVLITTGIKA PSKPTQKPQA MLSYGGVAMV THRSITIHMP ACFYSDDNGP ITKIQVIVAE
SGVKDNKNVT NWKSAYNDHP VPYFTDSGFT NPPCNGWSQR YNQTAAEYVI GKSDDCTGNN
TEHFCNGPLK PNSVYVFKFR ATNINGEYTD SEYSEHIKTG TAQIILGVLI HQRKKEGGTY
SPREAEIIET KCKLDQLIAV ADMELKQEKL NQLLSYRKSL KPVNKKSFLQ HVEDLCANDN
SKFQEEFSEL PKLLQDLATT DADLPWNKSK NRFPNIKPYN NNRVKLLSEP GTAGSDYINA
SFVSGYLCPN EFIATQGPLP GTVADFWRMI WETGTRTIAM LTQCYEKGRI RCHKYWPEDN
KPMSVFSDIL ISKVSEEVFP DWTIRTLKVE KHGHYILVRH FNYTSWPEHG VPESCSTLIK
FVKAVRMHRQ DNSTIVVHCS AGVGRTGVFI ALDHLIQHVR DHDFVDIYGL VAELRSERMC
MVQNLAQYIF LHQSTLELLN NKGNSQSIWF VSYSALEKMD SLDAMEGDVE LEWEETTM
//
