ID A0A3Q4ID39_NEOBR Unreviewed; 683 AA.
AC A0A3Q4ID39;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000029032.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000029032.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR RefSeq; XP_006780607.1; XM_006780544.1.
DR AlphaFoldDB; A0A3Q4ID39; -.
DR STRING; 32507.ENSNBRP00000029032; -.
DR Ensembl; ENSNBRT00000029788.1; ENSNBRP00000029032.1; ENSNBRG00000022106.1.
DR GeneID; 102788944; -.
DR GeneTree; ENSGT01080000257336; -.
DR OMA; LYLRIVK; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000022106; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF162; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 57..78
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 197..220
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 247..269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 330..351
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 367..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 528..551
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 617..639
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 19..645
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 446..501
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 683 AA; 74982 MW; 2A0EBAD74FEA7077 CRC64;
MSVESKKTRE ACCSKLKLFL ASLAFVYFAK AFAGAYMKSS ITQIERRFDI PSSLIGVIDG
SFEMGNLLII AFVSYFGAKL HRPRLIGIGC LIMAVGSFLV ALPHFFQGQY KYETSVSHKG
AVNSTETILP CLSNHSMTDA DDTLDAETKL ECEKAAGSPM WIYVFMGNML RGIGETPVMP
LGISYLDDFS REENTPFYLA CIHTVGILGP MFGFMLGSFL SKIYVDTGFV DLDTITITYK
DSRWVGAWWL GFIVTGTVVL LSSIPFFFLP KSLPKQGQEQ EEIQSKSTEL ATKTEQEQFL
PEETQEKPVK FQEMAKDFIP SLKRLFRNRI YSLIILASLV AVNGFIGLIT FKPKYIEQVY
GQSASKAIFL IGILNLPAVA LGFITGGFML KRFKLGVVGA ARVAISASLG SFCMFAVQIF
VQCDNAEVAG LTMSYQSVPQ VSYNPQTLLS QCNGQCFCSV KHWDPVCAYN GMTYASPCLA
GCQTSTGMGK EMVFHNCTCI NEAGLAANAS AVLGQCPRKD DCDMKFKIYM ALSVISSFIS
ACGGTPGYIV LLRSIQPDLK SLALGMQTLI VRTLGGIPPP IYFGALIDRT CLKWGTKHCG
GRGACRLYNA NAFRVTYLGM ITGLYFLANT VWGFLYYSIV KRQKKIALKN QSKENGQESN
AVTNGHANIN IADVDDMGME CTI
//
