ID A0A3Q4M2E1_NEOBR Unreviewed; 3066 AA.
AC A0A3Q4M2E1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=FRAS1-related extracellular matrix protein 2-like {ECO:0000313|Ensembl:ENSNBRP00000000854.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000000854.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000000854.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR STRING; 32507.ENSNBRP00000000854; -.
DR Ensembl; ENSNBRT00000000903.1; ENSNBRP00000000854.1; ENSNBRG00000000680.1.
DR GeneTree; ENSGT00940000155313; -.
DR OMA; ILPWELN; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000000680; Expressed in zone of skin and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 4.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR045658; FRAS1-rel_N.
DR PANTHER; PTHR45739:SF4; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 4.
DR Pfam; PF19309; Frem_N; 1.
DR SMART; SM00237; Calx_beta; 4.
DR SUPFAM; SSF141072; CalX-like; 4.
DR PROSITE; PS51854; CSPG; 12.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..3066
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018572404"
FT TRANSMEM 3012..3036
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 282..378
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 401..489
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 510..622
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 647..753
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 774..865
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 891..983
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1012..1114
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1135..1228
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1249..1345
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1366..1458
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1478..1567
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1601..1698
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1771..1881
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1898..2002
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2017..2119
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2137..2241
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT REGION 3043..3066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3050..3066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3066 AA; 341045 MW; B32BBAD3F9D7E6CF CRC64;
MAWIIHPHLH GTGAALILLA VILTGDVIAQ VFDSYGLSYA LRAELSEDTI LVANNGIRVP
FGRSVFIDPI NDLVIQVQPG DRCSITVLDN DPLSQRPGHL SPKKFPCEFG PNDVKYSHFG
SRSPPKDRVR LQLRYDTQTD TIIIPFMMEV EVIFTQLEVL TKNMPLTVEK LLGTSNPIDK
KILEFTYDRS AHQCKIASLS SGNVLPRYGK LVDEESLGTM VDCDEFIKMN TRYQHTFALK
SPNRDYIPMV VELHDKEGNL LKQEFFQILV RIKEGEDNIP PKPSFVAMMM MEVDQFVMTA
ITTDMLAAED VESNPDELIF NITSPLSFEE GYIVSTDDRN LPITSFYQGD LKELKIAYKP
PAVDSDTERI FQIEFEVVDG EGAVSDPFAF MIVVKPMNTL APVVTRNTGQ LLYEGQSRPL
SSSQNLEISD EDNLEKVKMT VIDGLRHGEL TVLGSRRKFF TPADLDAGVV IYQHDGSDTY
SDNIVFRMTD GTNEVEFLFP ITVVPTDDEP PIINANTGLV LFKNQMMPIT SLMLSAADID
SEDSTIKFTI EPPFSTLGQV MLRQSEAPED PSTWKFNTED EMYEKVVTEW LQQDITDGKL
FYKHIGPHST STIMDQFVFT VQDDNDPPNQ SGQGSFVIKI LPVDDLPPEL YPGATLQMTV
HEYQLTYFRK KFLRYTDLDS DDRDLKYTVV QPPTDTDENS PVVLGALVLT ENPNTEVTTF
TQAQINHHKI AYKPPDLELG ITTHVLQFRY TVEDVSGNTV EGVFTIFLKP VDNKPPQIKN
SGFTVLERGR HILTSAELDT SDTDTENKKI TFTLTQPPLH GQVQFTFTDM TKGNAFTLED
IANALISYIH NGDESTVDSI QIDVSDGVHI VPITIKINVK PIDDEAPTIS LPAGTIGSYI
DVLENGATEI TSNVIQGRDE DTDDLRLTFI VEDPPSLGEI LVRGVSSGTF TQADIINGFV
VYAHTSGEIG SSTKEDFFNL TLTDMSDEWT VGGNKITGVR VHVTILPLDS QAPEVFVGPQ
FTVVEGEKNV IQILHISADD VDTPSDDLLC TIIVQPTSGY VENISPAPGS EKSRSGTAIS
AFTIKDIKQN HIYYVQSIHK GVEPVEDRFT FRCSDGINFS ERHFFPISII PSNDEKPEIY
MREFVVMEGM NIVIDTPILN GADADLPSDH LTFIITKPPK HGFILNQLTT GTVPVSNFTL
DQIREASSYV YEHDDSETTE DSFDIVLTDG KFVAEKTVIV MIIPVDDETP RMAINDGLEI
EIGDVKVINS DVLKATDLDS EDSTLTYIIR YGPGQGYLQR ATPSGTLQNI TVGMNITQNE
VDQGLIVYIH NGQEGIRDLI KFDVTDGINP LIDRYFYVTI GSIDMVFPDV VSKGVSLKEG
GRVTLTTDLL STSDLNSPDE HLVFTITRAP VRGHLECTDT PGMPISSFTQ LQLAGNKIYY
IHTSDDEVKM DSFEFEVTDG YNPVFRTFRI SIADVDNKKP VLTVHSLAAT EGENKLITPF
ELTVEDRDTV DRLLKFTVTQ IPVHGRLLFN NTRPVTSFTK QDLNENLISY RHDGTESTED
SFSFTVTDGT HTDFYVFPDT VFETRKPQMI KITILSVDNG VPQVLVNKGA PTLRVLETGH
LGFVITSKTL KAEDRDSIQN SVTFRITVAP EHGYLINHAR GNATINSFTQ AEIDDMSICY
ILRDGDNATN DIFHFSIEDS GGNKLKNQQF RLNWAWISLE KQHYVVNEEA KFLEVVLKKR
GYLGETSFIS KQILHQKGSV LPCNGKHKKS QSIHVILTGK STVFIPSAVY NIEEDIGELL
IPVRRSGDVS QELMVICYTQ QVSATGTIPT TVLSYSDYIS RPEDHHSILR FDKGEIEKSC
RIVIIDDSLY EDEESFNVTL SMPMGGCLGS EFPTARITII PDMDDDPVFY FGNTGYHVDE
SDGYVEAQVW RTGTDLSKGG TVTVRSRKTD PVSAEAGVDY VGISRNLDFA PGVTMQTVRV
TILDDLGQPV LEGPEKFELV LRMPMNGILG EPSKTAIIIN DSVSDLPKVQ FREATYVGNE
NLGQISATVY RSGDISYKST VRCYSRQGTA QVMMDFNERP NTDASIITFL PGEIEKPCLL
VLVDDTEHEE EEELRLVLGS PKSDSPFGAS IGEQNETLIK IKDDGDKAII SFGETKFSVT
EPKESGQVSV VRIPVLRAGD TSKVSVVRVH TKDGSATSGE DYHPISEEII FKQGDREHFV
EVEILYDGVR EMREAFTVHL KPDENMVAET KQMSKAIIYI EETNSMADVT FPSVPRVVSL
LHYDDPDGTR GSLPVAGYPV ICVTACNPKY LDYDKTGSIC VSENINNTLT RYRWLVSAPT
GPDGVTSPMR EVDFDTFFTS SKMITLDSVY FQAGSRVQCA ARAVNSNGDE GLELTSPIVS
ISTDEGMCQP RVAGTVGAEP FSAKLRYSGA EDTDHPNLIK LTVTMPHIDG MLPVVSTRPL
SNFELTLSPD GTRVGHHRCS NLLDYTEVKT RYGFLSDATK NPEVIGETAP YQYSTSLRGS
STLRFYRNLN LEACLWEFTS YYDMSELLSD CGGTIGTDGQ VLNLVQSFVT LRVPLHVSYV
FHSPVGAGGW QHFDLQSELR LTFVYDTAIL WRDGIGSPPE AELQGALYPT SMRINSQGQL
VVNFRTEARF RGLFVFSHPA SLLTSMVMCP EHPGLTFNLS LVRTEPTYSQ PIQQWIFISD
FAVRDYSGMY TVKLLPCTSP PSLEYAVPPV CNPREPLTFD LDIRFQQVSD PVAAEFSLNT
QMILLSKRTL WLSDGSMGFG QESDTAFSEG DAVYGRVMVD PVQNLGSSFI CNIEKVFLCT
GADGYVPKYN PSNFEFGCLA DAPSLLYRFK IIDKAQPETQ ARVFGDVPFN AFLAVDDPGA
LALVRQPGSD GFRMDSTALF QVAAGREWYI HTIYTVRSKD NANRGIGKRS LEYHVMSQHT
DLLPKSQHRL RRSANDVLDI VEDIGVSNNR GTNILHIALD RSGQQRTSPD REIFTKGHIP
RELKERDSDD SLVLMIGIFV GLLLTVLVII VVVLLVRSKQ EKKEVPRNSS SAEPMMTQNI
SDNSEV
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