ID A0A3Q4M2T6_NEOBR Unreviewed; 838 AA.
AC A0A3Q4M2T6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSNBRP00000001114.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000001114.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000001114.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q4M2T6; -.
DR STRING; 32507.ENSNBRP00000001114; -.
DR Ensembl; ENSNBRT00000001168.1; ENSNBRP00000001114.1; ENSNBRG00000000918.1.
DR GeneTree; ENSGT01100000263565; -.
DR OMA; KHANFSA; -.
DR Proteomes; UP000261580; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 4.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF511; EXTRACELLULAR CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 2.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..838
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018586108"
FT TRANSMEM 572..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 767..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 573..837
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 838 AA; 93714 MW; 9E83BB02972BF094 CRC64;
MTLLIAWLFI FLYLMNNKHG SAAVLDNCVF WGEEDKNSLY EDGDVVIGGL FPLHYSPVFS
RSTYKEKPKT NMYNFSSRAL RWMQTMTFTI KEINGRSDLL PHLKLGFHIH DSCDDIPVSL
RASLDQVLKN NGSNVGCDAV RRTVSSVIIG DAGSGVSTAL LRSLGCFHIP LVSYFASCSC
LSNQREFPTF MRTMPSDTFQ IRALAQLVSY FGWTWVGVIG VESDYAHFAI QLFLQEYLCI
YVNIFLYLYI CRISNKTDFI LREIMHRNMT GLQWIASEAW ATAKSLWEKS GDLLMGTLGF
AIRRAATIPG LKQHLTSLTA SSLHKSAFLA EFWEETFDCR LNGSLNTHSH GSDNLFDRQP
CKGTEDLNDV YSPYSDVTQL RVSYNIYKAV YLVAYALQDL SNCKVGKGPF LNGTCADPKH
FKPWQVSQIM GANFSALGEK VNFDQNGDPI AYYDLMNWQR APDGSLNLVK VGFYDASLPG
HSLIINDSVI QWPLGKKAIQ SVCSSSCPPG TRVVRRKGEP ICCYDCVPCT EGEVSNKTDS
LECSRCSADT WSNTARNLCI PRTTEYLSYY EFMGILLCVA SVFGACLSLF IITIFISFKD
TPLVRANNME LSFLLLAFLA ICFLVGLLFI GVPSDWLCRI RYPAFGISFA LCISCLLAKT
AVVLMAFRST LPRSNVMKWF GSNQQRASVL LGTAVQVIIC FIWLLTSPPH ANNNTDYHGP
TIIKECVPGS EVGFWSVLGY IGILACGCLL MAFLARNLPD NFNEAKFIAF SMLIFFAVWI
TFIPVYVSTA GKYTVAVHIF AILASAFALL FCIFVPKCYI ILLRPEKNCK KKMMTPQP
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