ID A0A3Q4M3Y5_NEOBR Unreviewed; 1115 AA.
AC A0A3Q4M3Y5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Nuclear factor of activated T-cells, cytoplasmic 3-like {ECO:0000313|Ensembl:ENSNBRP00000001679.1};
GN Name=NFATC3 {ECO:0000313|Ensembl:ENSNBRP00000001679.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000001679.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000001679.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q4M3Y5; -.
DR STRING; 32507.ENSNBRP00000001679; -.
DR Ensembl; ENSNBRT00000001746.1; ENSNBRP00000001679.1; ENSNBRG00000001353.1.
DR GeneTree; ENSGT00940000156131; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000001353; Expressed in blood and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF6; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 456..637
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 88..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1088
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1115 AA; 121029 MW; BB98E50838CF9A90 CRC64;
MVDYFELPKR VAEGRRQVLV TRPYLEQENP SCPSSLQLFT AQTLCDLKEE RSGRMLCATM
SDLEPDDNTS FYILNVGQPQ SVVTNHQSMS LPRHGMPSHS PIINTSRLQT QKPGSEPPSY
DTQDSKYGTS PMLPSAPAPK AFECPSIQIT SISPSCPQEM DANQEDLRAN GPDGDYHSDR
PLSRDHLYLP LDHSYRDSSL SPSPCSSLSS RSWFSDASSC ESFSHVYDDV DSELNEAAAR
FNLGSPLTSP GCPSPQTGGG GVMEEQPHWQ HHQPTFVHQS HSISLSPRQS PCHSPRTSVT
DENWLSPRPP SRPSSRPTSP CGKRRHSSAD ICYPGSLSPH HSPTPTPGPS PRGSVTEDTW
VGSPSVGMSP FQCCPSEADI PSKTRKTSQD RTTMQTGKGE LGLDDQGNMS PNLDSPSDEA
LHSLKKDGPA EQFLSVPSHF SWNKPKPGHT PIFRTSSLPP LDWPLPSQFG QYELKIEVQP
KAHHRAHYET EGSRGAIKAT SGGHPVVKLI GYNEKPINLQ MFIGTADDRY LRPHAFYQVH
RITGKTVATA SQEIMVSSTK VLEIPLLPEN NMSASIDCAG ILKLRNSDIE LRKGETDIGR
KNTRVRVVFR VHIPQPNGKV LSLQAASIPV ECSQRSAQEL PQVEKSSLTS CLVSGGEEMV
ITGANFFPES KVIFLEKGPD GRPQWEVEAK IIHEKTQGSC IVVEIPPYHS KSVSSAVQVQ
FYVCNGKRKR SQSQRFTYLS VMVKQEHRDE LDLPAVPPIS MPRAPAGSLV RTQLPSPELG
HPSDNLLSSS PHGLATGSGP GLLPVQTPCP SLGSPSFQHL PQLQGRILHH PPADCQMTYH
PNSAPLSVPP HSSYQPMQHS HGHSLPFNGQ PSLSPQGYER MPFQQSPSAT SHPMGMGMLY
PSSPCSSPTA PSSTTTNPIE GSPQSQQPLF TPSCSHLQTL GSYHCSPTQV PSPGGHPLTG
QHSTPLQRAM GYHPVSQRSA SCPTTSSAPP PRMVPSPHSG PSSPQLHSLP YQSPTSSSPT
SGGSPLGPLQ QQHSGQLSPQ ATSPVMTSLS PAGVGPLVHP LSPQGPFQSD GERLSIKQEP
EDREPTFRSI GLQDITLDDV NEIIDRDMSQ SPNQS
//
