ID A0A3Q4M6M7_NEOBR Unreviewed; 321 AA.
AC A0A3Q4M6M7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA repair protein {ECO:0000256|PIRNR:PIRNR005856};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000003354.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000003354.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the homologous recombination repair (HRR) pathway
CC of double-stranded DNA, thought to repair chromosomal fragmentation,
CC translocations and deletions. {ECO:0000256|PIRNR:PIRNR005856}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR005856}.
CC Cytoplasm {ECO:0000256|PIRNR:PIRNR005856}.
CC -!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily.
CC {ECO:0000256|PIRNR:PIRNR005856}.
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DR AlphaFoldDB; A0A3Q4M6M7; -.
DR STRING; 32507.ENSNBRP00000003354; -.
DR Ensembl; ENSNBRT00000003473.1; ENSNBRP00000003354.1; ENSNBRG00000002689.1.
DR GeneTree; ENSGT00930000151053; -.
DR OMA; PCLGLQW; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000002689; Expressed in skeletal muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd19491; XRCC3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR047348; XRCC3-like_C.
DR PANTHER; PTHR46487; DNA REPAIR PROTEIN XRCC3; 1.
DR PANTHER; PTHR46487:SF1; DNA REPAIR PROTEIN XRCC3; 1.
DR Pfam; PF08423; Rad51; 1.
DR PIRSF; PIRSF005856; Rad51; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR005856};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005856};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 60..241
FT /note="RecA family profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50162"
SQ SEQUENCE 321 AA; 34951 MW; 5A8941AF76AEB601 CRC64;
LDWDKKSLKS VQDVVCASAP DLQRLTGLSN SDVQQLITAA AAVCRRHPPI TAQQLQHGVS
GAQLRLGCPV LDRLLRGGLP VGGITELAGE SGTGKTQVGL QLSLSVQYPA EHGGLGAGAL
YVCTEDSFPI KRLHQLIGEQ VCLRSDVPAD LVSSLCFSDH VYIEHAADLD SLLVCLTRRA
RLLLTRGLVR LIVVDSVAAL FRTEFQADDW LERNRQLLTF SSMLHHLSQE FSTPVLCINQ
VTPSRPSLST VSPALGLAWA NQVMVRLMMS RLQGTVVRGD QSSALRRLEV VFAPHLARDG
QNAAVWREGL RGVESWASNR K
//
