ID A0A3Q4M713_NEOBR Unreviewed; 1324 AA.
AC A0A3Q4M713;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Insulin receptor substrate 1-like {ECO:0000313|Ensembl:ENSNBRP00000003564.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000003564.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000003564.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 32507.ENSNBRP00000003564; -.
DR Ensembl; ENSNBRT00000003686.1; ENSNBRP00000003564.1; ENSNBRG00000002843.1.
DR GeneTree; ENSGT00940000166370; -.
DR OMA; PEAEMGH; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000002843; Expressed in muscle tissue and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF8; INSULIN RECEPTOR SUBSTRATE 3; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1294..1315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..115
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 138..242
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 240..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1011..1030
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1324 AA; 139790 MW; 70558221EB3F387A CRC64;
MESQAGEQHS HEDVRKSGYL RKHKSMHRRY FVLRAASERG PARLEYYESE KKFRGKAPVP
KKVVALETCF NINKRADSKN KHMIVLYTRA ESFAVAAENE ADQDEWYQAM VELQCRSKNP
NDGSGAGDYG VPNPGPAFKE VWQVKVWPKG LGQAKNLVGI YRLCLTDKTV NFVKLNSDAA
AVVLQLMNVR RCGHSENFFF VEVGRSAVTG PGEFWMQVDD SVVAQNMHET LLEAMKALSE
EFRQRSKSQS NSGPGGGATA SNPISVPSRR HHPNPPPSQV GFARRPRTEP PGGTNSGAPI
NCANASPTPR HSFPRSRTAS DGGKGEDGIT GATPIHGVNS SPSTNGSCSN TPILRSKSAR
SAPTTTAKTP LGLMRSISTP APSPAPSLSS SSGHGSEFGG LTSCAGAPGS GAYSRIPSHR
ASVSGSPSDY GSSDEYGSSP GDHTLLPSPS LPGSSVGSVS SQSLSEDGAN YILMSQRSSS
GGGNSNQGSG SQQTPGTPTS GSQTKRVLRR SSSRECEAER RLLSKRASLP PMALERLAPR
QRRAEEPADD DSADYAIMSR STSRESFTST CSSTQKESAM SAGSAGGGGA YLDVAGEFKA
EGTGGAGGSV DLGVDNGYMS MLPGVTQPPT SLSQSLAVSV PDSDSKPADD YMAMTPNNSV
SPPQQIRPPP TSDGYMIMSP NSSCSPDQRG GLSGGAWVGS GSADSRPGSD YMNMSPISAR
SVNGSPTPPE HSSHLETSPQ QHGPKMVYSY YSLPRSYKHS PSTGHFDDGP GRGRRPNGNS
RRGMGGGKPI RGLQEQAAVG NAVVGRHLSL SSSSYSSSSA SSESLGESDE RTTQALSNVT
GGTQSKDGSK QQQRRGSGGL SKQGSYTRSR PVSLFVDVSK ANTLPRVREN PLPPEPKSPG
EYVSIEFKGE KGNPTGIGLG RGRGLRHGLS LPHGSSSQQP QPKPSSSFGN FIPLSRSPSA
PITPPAASEY VNMDLGPSPS PSPLSLTPLV FPSFHTPPTP PTLAHAPKPC NEDNTEPHED
EVEVADAPLR KNRESVPSVT KSESPTSCGD YTEMAFSLNN NNVPRSSSSV SPKGPSPTRD
DTSVLPRGLD FPLSKTGPNP DQGAKVIRAD PQGRRRHCSE TFLASTSLST STSTSSSTAS
LFPEHQSVAR RLGFESMLWG NGVVTESPTQ FPLPGQQTLP TNAQTSSAEQ GLNYIDLDLA
NKESPHVGLD GPSGSQAPSR LFSGLGSGSG VGAAGASVGS SGSGSSSLNT YASIDFYKSE
ELRTHQNGSK EGTGKNCYFF PHFMSLSSYR LCDLYVTTML IGFLSLFSFP AITWLRMKKN
MLSR
//
