ID A0A3Q4M973_NEOBR Unreviewed; 705 AA.
AC A0A3Q4M973;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Endosialin-like {ECO:0000313|Ensembl:ENSNBRP00000004779.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000004779.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000004779.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_006808548.1; XM_006808485.1.
DR AlphaFoldDB; A0A3Q4M973; -.
DR STRING; 32507.ENSNBRP00000004779; -.
DR Ensembl; ENSNBRT00000004922.1; ENSNBRP00000004779.1; ENSNBRG00000003798.1.
DR GeneID; 102799497; -.
DR CTD; 323364; -.
DR GeneTree; ENSGT00940000156996; -.
DR OMA; APNKRIT; -.
DR OrthoDB; 19806at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000003798; Expressed in mesonephros and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0045088; P:regulation of innate immune response; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR CDD; cd03600; CLECT_thrombomodulin_like; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR14789; CHONDROLECTIN VARIANT CHODLFDELTAE; 1.
DR PANTHER; PTHR14789:SF4; ENDOSIALIN; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 4.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..705
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018711285"
FT TRANSMEM 642..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..163
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 293..330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 331..370
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 475..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 77859 MW; 4008C2021B1E8387 CRC64;
MGSLVSSAFL FSLLALLFGC SSVLAQNLRQ RDALCNTDGC FVVYFQRKTF LESWRACKEK
GGNLATIKRK VDATAIATLF STVDLRHSRT TVHVWIGLQR QPRQCTTTHP LRGFSWTTGD
QDTEYTDWQN PDSPDSCSAP RCVFMGYSTE DQDDNFKWID SACAVSADGY LCHYAYAGMC
PPLCSEGEGN VTYTTPFNLL SVLLTHVPVG SVATVRCPSG AKEEKTVSCM TREDGSVGWT
KETPLCSHFS ISRDLCDQDN GGCEHFCMPA GGHVYCECAD GYALAPDERT CLDVDECLGG
PCEQICVNTV GTFECQCHEG YDINDEGECE DIDECINDTC EHACENTPGS HICHCNLGYS
LVPEHPRQCQ DINECEIPGT CEQMCVNYEG GFECYCSEGF ELMSDNYSCE KREEGDDQYA
VTPPSLWVTG QAGPLWDYDW PTQEEESLDW LTESTRVLNS DVIWATSPPL VLVPLTQGTD
KDEEAVDRAD WSNGDQGSQS ELKVLSATTY NTPHLLSSSA TPDPYKEDES EATTALPSYP
TSTVSEGAWS WGADLVTSSE IPQRSVTDMP EESSYHKEPE GETQRNLLRE NFQFTEAELS
KEEMTFVEFT PSQNLAFPTG LASSQPPPTE DEEGVQTKRS TWLMVGLFIA ICIFIAVMVA
LGFVYCNRYR VTAHDKNAAD CYHWISGSHE KQGAPDPSAG VQSCV
//
