ID   A0A3Q4MBH5_NEOBR        Unreviewed;       547 AA.
AC   A0A3Q4MBH5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Sorting nexin-27-like {ECO:0000313|Ensembl:ENSNBRP00000006254.1};
GN   Name=SNX27 {ECO:0000313|Ensembl:ENSNBRP00000006254.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000006254.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000006254.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q4MBH5; -.
DR   STRING; 32507.ENSNBRP00000006254; -.
DR   Ensembl; ENSNBRT00000006443.1; ENSNBRP00000006254.1; ENSNBRG00000004884.1.
DR   GeneTree; ENSGT00950000183212; -.
DR   OMA; SGLHCTG; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000004884; Expressed in brain and 2 other cell types or tissues.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR   GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR   CDD; cd13338; FERM-like_C_SNX27; 1.
DR   CDD; cd01777; FERM_F1_SNX27; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd06886; PX_SNX27; 1.
DR   Gene3D; 1.20.80.60; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR037831; SNX17/27/31-like.
DR   InterPro; IPR037827; SNX27_FERM-like_dom.
DR   InterPro; IPR037833; SNX27_PX.
DR   InterPro; IPR037835; SNX27_RA.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12431; SORTING NEXIN 17 AND 27; 1.
DR   PANTHER; PTHR12431:SF17; SORTING NEXIN 27B; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS50200; RA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Transport {ECO:0000256|ARBA:ARBA00022927}.
FT   DOMAIN          50..143
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          168..276
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   DOMAIN          280..369
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  61869 MW;  2A1B540EAD90ECC0 CRC64;
     MADVAGQEIC SPVPPSPHPS SGNGSGSGNV TPGTGGSCQT ATTVTSGPRL VRIVKSDSGY
     GFNVRGQVSE GGQLRSINGE LYAPLQHVSA VLPGGAADRA GISKGDRILE VNGVNVEGAT
     HKQVVDLIRA GERELVLAVL SVPPQEADCL DPGDDGSAQS CYDYSDKQAV PISVPSYKHT
     ELNHEKFVVY NVYMAGRQLC SKRYREFVIL HQNLKREFAN FTFPKLPGKW PFSLSEQQLD
     ARRRGLEEYL EKVCSVRVIG ESDIMQEFLS ESDENYNGVS DVELRIAMPD KTTLTVRVRK
     NSTTDQVYQA VVMKLEMDSV TASYFALFEV INHTFVRKLA PNEFPHKLYV QNYTSAIPGT
     CLTLRKWLFT TEEEILLNDN QLAVNYFFHQ AVDDVKKGFI KVEQKSYQLQ KLAEQKKMSM
     YLSLLRTCEG YNEIIFPHCS CDSRRKGHVI TAISIHHFKL HACTEEGTLE NQVIAFDWGE
     MQRWDTDEEG MAFCFEYARG EKKPRWVKIF TPYFNYMHEC FERVFCELKW RKENIFQLLR
     HRRDGGT
//