ID A0A3Q4MGF8_NEOBR Unreviewed; 606 AA.
AC A0A3Q4MGF8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Complement C8 alpha chain {ECO:0000313|Ensembl:ENSNBRP00000009494.1};
GN Name=C8A {ECO:0000313|Ensembl:ENSNBRP00000009494.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000009494.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000009494.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A3Q4MGF8; -.
DR STRING; 32507.ENSNBRP00000009494; -.
DR Ensembl; ENSNBRT00000009761.1; ENSNBRP00000009494.1; ENSNBRG00000007346.1.
DR GeneTree; ENSGT00940000160126; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000007346; Expressed in liver and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF1; COMPLEMENT COMPONENT C8 ALPHA CHAIN; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50092; TSP1; 2.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..606
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018573298"
FT DOMAIN 170..526
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DISULFID 149..161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 168..183
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 606 AA; 68293 MW; 08C83F07DABFA3E6 CRC64;
MGTFLRLLLG LCTLHLFVSS DTIVDASRTP WTTAKNRYSI FHLTTSCIYT LIAFIYHIPC
TMGFTNGTKI IIIIMWVRRA RAVNKPTPID CRLGSWSSWT PCDSCTDRKF SFRYLEKPSQ
FGGTECTDIL WRREMCPTST TPCLVPDYCE ESFTCKETGR CISRSLQCNG ESDCDDLSDE
DGCENVNQRN DKCSTLIPIP GCEYVYNGEW RKFTYDAFCE NLHYNEDEKN YRKPYNYHTY
HFMAQASSKG SSEYFDDMVS LLKARKTVSS SNGGFTVGIY HVEVGLGGSN EKSFLKNITQ
FKSQDLGFIW LNSEVQTARF KMRTNKLMLH EDFYVSLMEL PEEYDFGMYS RFFNTFGTHY
ITEGTMGGTL EHVVIVNKTT MRNLNINADQ AGSCFGASFG LSIPVGSSAA IEPKLSGQLC
DKGGHFSEGE KWKFYRRGSS AIIQDVVTKV SGGITDRSAG LRAIRNPDMY RKWGLSLKYN
PTLIDYEIMP IHELVRISTA ADHVGDRLAN LQRAIDEYLQ QFDPCRCAPC SNNGIPVLSG
TSCNCICKYK ACDLCQIQMC DGSWSCWGAW SPCTSRRKTR TRVCNNPPPQ NGGATCLGSA
SQTWPC
//