GenomeNet

Database: UniProt
Entry: A0A3Q4MGF8_NEOBR
LinkDB: A0A3Q4MGF8_NEOBR
Original site: A0A3Q4MGF8_NEOBR 
ID   A0A3Q4MGF8_NEOBR        Unreviewed;       606 AA.
AC   A0A3Q4MGF8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Complement C8 alpha chain {ECO:0000313|Ensembl:ENSNBRP00000009494.1};
GN   Name=C8A {ECO:0000313|Ensembl:ENSNBRP00000009494.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000009494.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000009494.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC       {ECO:0000256|ARBA:ARBA00009214}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   AlphaFoldDB; A0A3Q4MGF8; -.
DR   STRING; 32507.ENSNBRP00000009494; -.
DR   Ensembl; ENSNBRT00000009761.1; ENSNBRP00000009494.1; ENSNBRG00000007346.1.
DR   GeneTree; ENSGT00940000160126; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000007346; Expressed in liver and 2 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR   InterPro; IPR048831; C8A_B_C6_EGF-like.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR001862; MAC_perforin.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR020863; MACPF_CS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR   PANTHER; PTHR45742:SF1; COMPLEMENT COMPONENT C8 ALPHA CHAIN; 1.
DR   Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   PRINTS; PR00764; COMPLEMENTC9.
DR   SMART; SM00192; LDLa; 1.
DR   SMART; SM00457; MACPF; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SUPFAM; SSF57424; LDL receptor-like module; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
DR   PROSITE; PS00279; MACPF_1; 1.
DR   PROSITE; PS51412; MACPF_2; 1.
DR   PROSITE; PS50092; TSP1; 2.
PE   3: Inferred from homology;
KW   Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW   Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..606
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018573298"
FT   DOMAIN          170..526
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
FT   DISULFID        149..161
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        168..183
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   606 AA;  68293 MW;  08C83F07DABFA3E6 CRC64;
     MGTFLRLLLG LCTLHLFVSS DTIVDASRTP WTTAKNRYSI FHLTTSCIYT LIAFIYHIPC
     TMGFTNGTKI IIIIMWVRRA RAVNKPTPID CRLGSWSSWT PCDSCTDRKF SFRYLEKPSQ
     FGGTECTDIL WRREMCPTST TPCLVPDYCE ESFTCKETGR CISRSLQCNG ESDCDDLSDE
     DGCENVNQRN DKCSTLIPIP GCEYVYNGEW RKFTYDAFCE NLHYNEDEKN YRKPYNYHTY
     HFMAQASSKG SSEYFDDMVS LLKARKTVSS SNGGFTVGIY HVEVGLGGSN EKSFLKNITQ
     FKSQDLGFIW LNSEVQTARF KMRTNKLMLH EDFYVSLMEL PEEYDFGMYS RFFNTFGTHY
     ITEGTMGGTL EHVVIVNKTT MRNLNINADQ AGSCFGASFG LSIPVGSSAA IEPKLSGQLC
     DKGGHFSEGE KWKFYRRGSS AIIQDVVTKV SGGITDRSAG LRAIRNPDMY RKWGLSLKYN
     PTLIDYEIMP IHELVRISTA ADHVGDRLAN LQRAIDEYLQ QFDPCRCAPC SNNGIPVLSG
     TSCNCICKYK ACDLCQIQMC DGSWSCWGAW SPCTSRRKTR TRVCNNPPPQ NGGATCLGSA
     SQTWPC
//
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