ID   A0A3Q4MIS6_NEOBR        Unreviewed;       657 AA.
AC   A0A3Q4MIS6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Thyroid peroxidase-like {ECO:0000313|Ensembl:ENSNBRP00000011549.1};
GN   Name=TPO {ECO:0000313|Ensembl:ENSNBRP00000011549.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000011549.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000011549.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q4MIS6; -.
DR   Ensembl; ENSNBRT00000011876.1; ENSNBRP00000011549.1; ENSNBRG00000008901.1.
DR   GeneTree; ENSGT00940000158104; -.
DR   Proteomes; UP000261580; Unplaced.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR   PANTHER; PTHR11475:SF60; THYROID PEROXIDASE; 1.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   PRINTS; PR00457; ANPEROXIDASE.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   4: Predicted;
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   BINDING         388
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   657 AA;  75202 MW;  80ED5F1FAC949ED8 CRC64;
     MLKFFRQADP ETKHISKAAE VFQKTLRVLK KKVKQRYNQE KLDVAFSKGL YSFAWHYFWT
     HFMFLFVRQN PRWGAANTAL VRWLPAEYED GESEPKGWNP ERLHNGFQLP PARTVSREIM
     TSASKWKDDS YSQLLVDWGQ YISHDITLTP QSTSTDGSGV DCLKTCENVH PCFPIQLDDK
     RSPAQSCMPF FRSTSDCFVN FQSGIRQALQ RQQLNAMTSF IDASAVYGRD LKLESFLRDL
     PGRNGKLAVN ARFKDPKGRP YLPFVTKLPS ACHQDLQGER VECFSAGDNR VSEGLPLTSL
     HTLWLREHNR IAEALKHING HWSPEMIYQE TRKIIGALHQ IITLRDYAPK IIGPESFKDY
     IGPYRGYDPS VDPSIANVFA TAAFRFGHAT ISPILYRLNE SFQEDERFPH LRLHNTLFSP
     WRIVKEGGIE PVLRGVIGSA ASAVSADMLL ADEVTERLVV LDTLKQMDLA ALNLQRGRDH
     GLPGYNDWRE FCGLQRIKTL DDLSLAVGDC RVAKRILDIY KHPDNIDVYP GGLVERLLPG
     SRTGPLFACL IGRQMKVLRD GDRFWWEADG VFTQQQKEEL LKFSLSHLIC DNSDIGEVPP
     DPFRLGNYPS HYVSCDQIPS MNLVAWKEEM GEDNKNNTMF FDATEREMLH EFIIKFK
//