ID A0A3Q4MKC6_NEOBR Unreviewed; 773 AA.
AC A0A3Q4MKC6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=F-BAR domain only protein 2 {ECO:0000256|ARBA:ARBA00018998};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000012814.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000012814.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004283}.
CC -!- SIMILARITY: Belongs to the FCHO family.
CC {ECO:0000256|ARBA:ARBA00011064}.
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DR AlphaFoldDB; A0A3Q4MKC6; -.
DR Ensembl; ENSNBRT00000013179.1; ENSNBRP00000012814.1; ENSNBRG00000009710.1.
DR GeneTree; ENSGT00940000157105; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000009710; Expressed in blood and 7 other cell types or tissues.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR CDD; cd07673; F-BAR_FCHO2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR030122; FCHo2_F-BAR.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR018808; Muniscin_C.
DR PANTHER; PTHR23065:SF8; F-BAR DOMAIN ONLY PROTEIN 2; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF10291; muHD; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580}.
FT DOMAIN 1..240
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 505..773
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 245..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 77..146
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 421..435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 773 AA; 85834 MW; 465D54BFAC6A5910 CRC64;
LGEKNNGFDV LYHNMKHGQI STKELTDFIR ERSTIEEAYA RSMTKLAKSA GNFSQLGTFA
PMWDVFKGST EKLASCHMEL VRKLQELIKE VQKYVEEQSK AHKKTKEEVA STLEAVQNIQ
SIFQALQKSK ENYNAKIVEQ ERLRKEGATQ RDVDKAGVKA KKATETYKSY VEKYATAKSE
FEQKMTETAQ KFQDIEENHI LHMKEIIQSY SLYVDETHIQ IGEVHHEFVR NIENTSVESL
IQKLAESKGT GKERPGKPPG SSKPRRRKLL IPGRRKDKDT DSTKKNCILL VFLQNVPQVD
EEGFCIRPEV NENDILFCLS LNSFYSSSDS EDEDEPRKFH VQIKPVQPNN GVHQNQANID
ELKASIGNII LSPSTSVRSV DCDLKIKVIN NFSCSLSSTD QNKYVFLCLV PVLNRPTTPL
APGALVPPPR PSSRPKLPAG KLTGINEIVR PFSPPKASSP TPTAPLARAE SSSSLSSNAS
LSAGNTPTVG TSRGPSPVTL ASQDALPIAV AFTESVNAYF KGADPTKCIV KITGDMTLSF
PMGIIKVFTT NPSPAVLTFK LKNTSRLEQI LPNQQLLYSD PSQSDSDSKD FWFNMQALTS
YLRKASEQSP SASYYNVDIL KYQVMSDGIH STPLNLAVYW KCTASTTDLR IDYRYNPESM
DSPSPLTNVQ ILVPVDGGVT NMQSLPNSIW NSEQSKCLWR LTDISEKSEN DGAGSLRAKF
ELSNGPSHPS TLAVQFMNEG STLSGVDMEL QGAGYRLSLS KKRFATGRYM ADC
//