ID   A0A3Q4MNF3_NEOBR        Unreviewed;       828 AA.
AC   A0A3Q4MNF3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Eukaryotic translation initiation factor 4 gamma 2 {ECO:0000256|ARBA:ARBA00040449};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000015214.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000015214.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Appears to play a role in the switch from cap-dependent to
CC       IRES-mediated translation during mitosis, apoptosis and viral
CC       infection. Cleaved by some caspases and viral proteases.
CC       {ECO:0000256|ARBA:ARBA00037759}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC       {ECO:0000256|ARBA:ARBA00005775}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q4MNF3; -.
DR   STRING; 32507.ENSNBRP00000015214; -.
DR   Ensembl; ENSNBRT00000015629.1; ENSNBRP00000015214.1; ENSNBRG00000011756.1.
DR   GeneTree; ENSGT00940000154675; -.
DR   OMA; RSEQRDW; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000011756; Expressed in liver and 9 other cell types or tissues.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd11559; W2_eIF4G1_like; 1.
DR   Gene3D; 1.25.40.180; -; 3.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045208; IF4G.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   InterPro; IPR003307; W2_domain.
DR   PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR   PANTHER; PTHR23253:SF82; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2; 1.
DR   Pfam; PF02847; MA3; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SMART; SM00544; MA3; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; ARM repeat; 3.
DR   PROSITE; PS51366; MI; 1.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          465..588
FT                   /note="MI"
FT                   /evidence="ECO:0000259|PROSITE:PS51366"
FT   DOMAIN          642..825
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          366..392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   828 AA;  94631 MW;  59926E5B9A476A1D CRC64;
     APQHYPKTVG NSEFLGKTPG SSVQRWVPSR STRRDASSSN EKGQNDAIFR KVRGILNKLT
     PEKFDKLCLE LLNVGVDSKV VLKGIILLIV DKALEEPKYS QLYAQLCLRL AEDAPNFEAP
     TTESQATQKQ NSTFRRLLIS KLQDEFENRA RNVDHFDKHD SPLTSEEEEQ RAIAKIKMLG
     NIKFIGELGK LNLIHESILH KCIKTLLDKK KRVPLKDMGE DLECLCQIMK TVGPKLDHEK
     AKSLMDQYFA RMHSLTTSKD LPSRIRFLLQ NTVELRHNNW VPRKAYVDNG PKTITQVRQD
     AVKDLGVFIP PSTDSIRNDF FMDSSFLTGK IKYDRETLGG LADMFGQMPG IAPGVIQDHY
     SPTMGRHRSS PLFNGHSGNS NGSHQPYENE SKPFIKPNQI SLRPAQSFIM NKNQVPKLPP
     QTMIFRKCML SFLFVAPQLG LKANPPPIQE KPAKSNKKAP PTKEELCKMT ETLLTDYLNN
     KNVNDAVSAV KEMKAPKHFL SEMLNKIIVC SLNRSDEDKE HASTLIHTLC TEGLITGDNI
     LQAFLGVLDQ CPKIEEEIPL VKSYLAQFAA RAIIADLVSI ADLAHQLENG AHFPLFLLCL
     QQLVKLKDRE WLTDLFQQSK VNMQKMLPEI DQNKDRMLEI LEGKGLSFLF PLMKLEKELL
     KQIKVDPSPQ SIYKWIKDNI SPKLHTDRGF VNILMTSFLQ YIAYEINPDD DEEQHAAPSK
     DQLEEEKQLL LSFKPVLQKF LHDHIELQVS ALYALQVHCN AKRFPKGMLL RYFVNFYDME
     IIEEEAFLSW KEDLTQEYPG KGKALFQVNQ WLTWLETAEE EESEDEEY
//