ID A0A3Q4MSD3_NEOBR Unreviewed; 538 AA.
AC A0A3Q4MSD3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Lysosomal cobalamin transport escort protein LMBD1 {ECO:0000256|ARBA:ARBA00039618};
DE AltName: Full=LMBR1 domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042599};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000018244.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000018244.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009901}.
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DR RefSeq; XP_006800826.1; XM_006800763.1.
DR AlphaFoldDB; A0A3Q4MSD3; -.
DR STRING; 32507.ENSNBRP00000018244; -.
DR Ensembl; ENSNBRT00000018734.1; ENSNBRP00000018244.1; ENSNBRG00000014043.1.
DR GeneID; 102786995; -.
DR CTD; 55788; -.
DR GeneTree; ENSGT00390000002581; -.
DR OMA; FWAQFVF; -.
DR OrthoDB; 8533at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000014043; Expressed in camera-type eye and 9 other cell types or tissues.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR16130:SF2; LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1; 1.
DR PANTHER; PTHR16130; LYSOSOMAL COBALAMIN TRANSPORTER-RELATED; 1.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 234..289
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 538 AA; 60992 MW; 0F606192FF981C01 CRC64;
MAAQSLLTES VLGWSIFTVI LLVILVFCWI YIRKFQSRRE SEVISTITAI CALAIALITS
ALLPVDIFLV SFMKYPNGTY KEWAANNETR GQIEDTVLYG YYTLYSIILI CVFLWIPFVY
FYYEERDDNN VNKCSQVKNA LKYTIGFVIV CVALLLIGAF VPLAAPPGQN STQWEKVQYL
FEELGSSHGL PALSFSISSL TLIGMLAVIT YTAYGMSVMP LNLIKGTRSV KYERLENTED
IDDVEHQIEK LKSKCQDGRP LSSRDRNNLQ ELEGKLQVLR RRGRHLEIAE RNCCTKVGSA
LRPFKILLGI FFILVALLFT IALFISNLDK ALHSAGISSG FIIFGTNLTN PLNELLLALQ
PVFPLDYILI TVITVYFVLT SMAGIRNMGI WFFWIRLYKI RPKKTRPQAL LFLCMILLLI
VLHTSYMIYS LAPQYVMYGS QKYLVQMPSP GPTSGNTTIN TSRICDADAP EDQCTVTRSY
LFLHKFWFFS TIYYFGNWAF IGAFLIGLVV SCCRGKKSVI EGEVEADDSD FSDDEYVH
//
