ID A0A3Q4MSF9_NEOBR Unreviewed; 785 AA.
AC A0A3Q4MSF9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Carnitine O-palmitoyltransferase 1, liver isoform-like {ECO:0000313|Ensembl:ENSNBRP00000018294.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000018294.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000018294.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR RefSeq; XP_006805803.1; XM_006805740.1.
DR RefSeq; XP_006805804.1; XM_006805741.1.
DR AlphaFoldDB; A0A3Q4MSF9; -.
DR STRING; 32507.ENSNBRP00000018294; -.
DR Ensembl; ENSNBRT00000018784.1; ENSNBRP00000018294.1; ENSNBRG00000014091.1.
DR GeneID; 102784489; -.
DR GeneTree; ENSGT01060000248595; -.
DR OMA; ASDIDFH; -.
DR OrthoDB; 1429709at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000014091; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF114; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16484; CPT_N; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..47
FT /note="Carnitine O-palmitoyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16484"
FT DOMAIN 174..755
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT REGION 765..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 473
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 785 AA; 89386 MW; D7F5C5B5D825881D CRC64;
MAEAHQAVAF QFTVTPDGID LQLSHQALTE IYLSGMRSWK KRIVRIKNSV ITGVYPASPS
SWLFVVIAIL ATMYTRSDPS MGLIAKIQEH LPVSQSMSTQ CQAVVSAVLF STMLWLMLIF
TMRLCLKQLL SYHRWMFEQH GKMSTTTKIW VALVRIFSGR KPLLYSYQGS LPNLPVPTIK
DTVKRYLESV RPLMDDKEYE RMTKLAAEFE SSLGNRLQWY LKLKALWASN YVSDWWEEYV
YLRGRSPIMV NSNYYGMDFL YVTPTPIQAA RAGNSIHSFF LYRRKLNKEE LKPSRIPGTV
IPLCAAQCER IFNTTRIPGE ETDTVQHWQD SDYIVVYHRG RYFRLRVYQA GRLLSPREIE
FQIQRILDDP SPPSKGEAKL GALTAGDRVP WAKARTKYFS SGINKRSLDC IEKAAFFVTL
DDEEQGMMGD DPAASLDRYA KSLLHGKCYD RWFDKSFTVV YYKNGKNGIN AEHSWADAPV
LAHVWEYTLA NDSFQLGYNA EGHCKGDVDP SLPRPVKLSW EIPPECEEQI AQSLAVAQAL
ADDVDFHVFS FQEFGKGKVK KCRVSPDGFI QMALQLAYFR ERGTFCLTYE ASMTRLFREG
RTETVRSCTN ESSAFIRALE GGEAADVCKH LFRVATEKHQ LLYRLAMTGA GIDRHLFCLY
VVSKYLGVES PFLKEVLSEP WRLSTSQTPI QQVELFDIDN HPEYVSCGGG FGPVADDGYG
VSYCVLGENM INFHISCKHS CPDTDAHKFG DQIRQALRDL LKLLSPSQTE ASKTEESQPK
VKKEQ
//
