ID A0A3Q4MZ33_NEOBR Unreviewed; 798 AA.
AC A0A3Q4MZ33;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Extended synaptotagmin-1-like {ECO:0000313|Ensembl:ENSNBRP00000022914.1};
GN Name=ESYT1 {ECO:0000313|Ensembl:ENSNBRP00000022914.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000022914.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000022914.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the extended synaptotagmin family.
CC {ECO:0000256|ARBA:ARBA00005867}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q4MZ33; -.
DR Ensembl; ENSNBRT00000023513.1; ENSNBRP00000022914.1; ENSNBRG00000017095.1.
DR GeneTree; ENSGT00940000156561; -.
DR OMA; HPGQSKE; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000017095; Expressed in skeletal muscle tissue and 8 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0061817; P:endoplasmic reticulum-plasma membrane tethering; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd08391; C2A_C2C_Synaptotagmin_like; 2.
DR CDD; cd04050; C2B_Synaptotagmin-like; 1.
DR Gene3D; 2.60.40.150; C2 domain; 4.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037733; Ext_Synaptotagmin_C2A.
DR InterPro; IPR037749; Ext_Synaptotagmin_C2B.
DR InterPro; IPR031468; SMP_LBD.
DR InterPro; IPR039010; Synaptotagmin_SMP.
DR PANTHER; PTHR45761:SF3; EXTENDED SYNAPTOTAGMIN-1; 1.
DR PANTHER; PTHR45761; EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C; 1.
DR Pfam; PF00168; C2; 4.
DR Pfam; PF17047; SMP_LBD; 1.
DR SMART; SM00239; C2; 4.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 4.
DR PROSITE; PS50004; C2; 4.
DR PROSITE; PS51847; SMP; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 49..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 100..290
FT /note="SMP-LTD"
FT /evidence="ECO:0000259|PROSITE:PS51847"
FT DOMAIN 289..418
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 419..530
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 531..654
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 660..791
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 798 AA; 90138 MW; DA6055D55B44C930 CRC64;
MPTADAEPGI GTEPLAPVSE NQPQGERAVS VLWSFGKCLG ALLPVYLAGY YGLSVSIVLF
GLVIYMGWKH GRQEKVMRLK SAMYLLDNER EFTTQTVFRA KRDLPPWVST DTPSVRVILC
RILQQAWPFI GQYLEKLLVE IIAPAIRTSS IHLQTLSFTK VNIGDKALKV AGVKAHTEND
KRQVMLDLYL SYAGDVEINV EIKKYFCKAG VKGVQLHGML RVILEPLIGN IPLVGAVTMF
FIRRPKLDIN WTGLTNLLDI PGLNAMSDTM IMDAIASHLV LPNRLTIPLV ADLHVAQLRS
PLPRGVVRIH LLEAEDLTAK DTVIKGLIDG KSDPYAVLRV GTQIFTSHHV DSNLNPQWRE
MYEVIVHEVP GQELEVEVFD KDPDQDDFLG RDVASGSVHL RLEWLSLLSS ADRLTEVIAK
NQNLTSKVAE PPSAAILAVY LDQAYELPMR KGNKDPSPMV QISVQDKTKE SKTCYGTTSP
VWEDAFTFFI KDPHKQNIDI QVKDDDRALS LGSLKIPLAR LVGVPELTMD QWFQLENSGS
ASRIFIKIVL RVGISHTQIL KHLFCDNFMG GMVKGKSDPY VKIRVGGITF RSHTIKENLN
PVWNELYEVI LTQLPGQEIQ FELFDKDIDQ DDFLGRFKLS LRDIISARYT DTWYTLNDVK
SGRVHLMLEW LPRVSDLSRL EQVQYFYFPL SNDLDAPTRS KDGADPYISF ILLPDKKATT
KRKTVTKKKD LSPEFNERFD FDLSVEESSQ RRLDLSVKNS VSFISREKEL IGKLQLDLDQ
IDLKTGVTQW YDLAAETN
//
