ID A0A3Q4MZQ1_NEOBR Unreviewed; 373 AA.
AC A0A3Q4MZQ1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Snurportin-1 {ECO:0000256|ARBA:ARBA00016034};
DE AltName: Full=RNA U transporter 1 {ECO:0000256|ARBA:ARBA00031454};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000023414.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000023414.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an U snRNP-specific nuclear import adapter.
CC Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import
CC of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
CC {ECO:0000256|ARBA:ARBA00003975}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the snurportin family.
CC {ECO:0000256|ARBA:ARBA00007540}.
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DR RefSeq; XP_006782503.1; XM_006782440.1.
DR AlphaFoldDB; A0A3Q4MZQ1; -.
DR STRING; 32507.ENSNBRP00000023414; -.
DR Ensembl; ENSNBRT00000024028.1; ENSNBRP00000023414.1; ENSNBRG00000017919.1.
DR GeneID; 102797497; -.
DR CTD; 10073; -.
DR GeneTree; ENSGT00510000047494; -.
DR OMA; VQLSEWM; -.
DR OrthoDB; 197726at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000017919; Expressed in blood and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR GO; GO:0061015; P:snRNA import into nucleus; IEA:InterPro.
DR CDD; cd09232; Snurportin-1_C; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR017336; Snurportin-1.
DR InterPro; IPR024721; Snurportin-1_N.
DR InterPro; IPR047857; Snurportin1_C.
DR PANTHER; PTHR13403:SF6; SNURPORTIN-1; 1.
DR PANTHER; PTHR13403; SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1; 1.
DR Pfam; PF11538; Snurportin1; 1.
DR PIRSF; PIRSF037955; Snurportin-1; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW ProRule:PRU00561}.
FT DOMAIN 11..73
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REGION 67..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 118
FT /note="Interaction with m3G-cap structure"
FT /evidence="ECO:0000256|PIRSR:PIRSR037955-1"
FT SITE 157
FT /note="Interaction with m3G-cap structure"
FT /evidence="ECO:0000256|PIRSR:PIRSR037955-1"
FT SITE 290
FT /note="Interaction with m3G-cap structure"
FT /evidence="ECO:0000256|PIRSR:PIRSR037955-1"
SQ SEQUENCE 373 AA; 42572 MW; 25E08BE13C0905C7 CRC64;
MDDLTQALSA SFAVSKEPNS TACPHPRLAQ YKSKYSVLEQ SERRQRFLDW QKSKRLNYVN
HARRLADGDW TGADSDGEED MEKQEDGERA QDGNTEEEEM EIERRKLPKH YANQLMLSEW
LVDIPSELDT DWLMVVSPVG KRSLIVASKG STAAYTKSGY CVNRFPSLLP GGNRHNSAMG
KDYTILDCIY SEVDRTYYIL DVMCWRGHPV YDCPTEFRFF WLQSKVQETD NLSEITKRNP
FRFVGLQSTD CTAESIKAAL AAEYSFSVDG LLFYHRQTHY TPGSTPLVGW LRPYMVTDIL
GIEVPAGPLT KKPEYASHQL QQILEHKKTS SEVRPANRSG GYELEYLSTP NQGSEDTLDS
LKQTPIREAY MEI
//
