ID A0A3Q4N5M5_NEOBR Unreviewed; 867 AA.
AC A0A3Q4N5M5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Low-density lipoprotein receptor-related protein 12-like {ECO:0000313|Ensembl:ENSNBRP00000027499.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000027499.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000027499.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00037878}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR RefSeq; XP_006795288.1; XM_006795225.1.
DR AlphaFoldDB; A0A3Q4N5M5; -.
DR Ensembl; ENSNBRT00000028217.1; ENSNBRP00000027499.1; ENSNBRG00000020975.1.
DR GeneID; 102776305; -.
DR CTD; 29967; -.
DR GeneTree; ENSGT00940000158307; -.
DR OrthoDB; 2916406at2759; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000020975; Expressed in skeletal muscle tissue and 7 other cell types or tissues.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF47; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 12; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 5.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..867
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018608775"
FT DOMAIN 39..151
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 246..359
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 613..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 158..170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 165..183
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 177..192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 226..241
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 382..397
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 420..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 438..450
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 445..463
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 457..472
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 867 AA; 95075 MW; E26E7A3C29847F6D CRC64;
MALRTDCRQG VVCLLLLTGC IAVSQRNENV YVSGISNACS DVAELLRASS GIITSPGWPF
QYPARLNCSW NIRARPGDAI TISFQDFDLQ GSHRCTSDWM SISSYRNLDG LRVCGSSLPP
PYISSQDHLW IHFHSDDSLT GKGFRLSYIS GKPLASSCDV DQFHCSNGKC IPDWWRCNSM
DECGDNSDEE MCVDSPFSFQ PCSLNQFPCL SRYTRIYTCL PHSLRCDGSI DCQDLGDEID
CDVPTCGELL RNFYGSFSSP NYPDFYPPGS NCTWLIDTGD HRKVILRFTD FKLDGTGYGD
YVKVYDGLEE NPRRLLRVLT AFDSRAPVAV VSSSGQLRVH FYADKINAAR GFNVTYQVDG
FCLPWEVPCG GNWGCYTEQQ RCDGYWHCPN GRDELNCSSC QEDEFPCSRN GACYPRSDRC
NYQNRCPNGS DEKNCFFCQP GNFHCKNNRC VFESWVCDAQ DDCGDGSDEE SCPVIVPTRV
ITAAVIGSLI CGLLLVIALG CTCKLYSLRM FERRSFETQL SRVEAELLRR EAPPSYGQLI
AQGLIPPVED FPVCSGSQAS VLENLRLAVR SQLGFTSLRL PSSGRRSNLW RRLFNFSRSR
RSGSLALVSA DLEDSAGTGS TGSSGSDLLS PDSDDTDTEG ERGRGISAVG GPVAPLPQKT
PPPSAVEAVL SVTPSVTLTS GRDNDRPREA LPPSSPVTIV TSSPDPECHS DTSDLPAPAA
SALQRLAQNL HRLARNLTRT SQNQQSQTWT NHSPLHQLET GRGGVEVTER RGSGEEDEDV
ELLIPISDSD SSSSSLLVSD IRQPLLESYP SSTVNHAPRH HNGNSGRGGR DGPCEHCGMV
HTAQIPDACL EATGKTESSD DELLLLC
//
