ID   A0A3Q4N8J3_NEOBR        Unreviewed;       993 AA.
AC   A0A3Q4N8J3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000029599.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000029599.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q4N8J3; -.
DR   STRING; 32507.ENSNBRP00000029599; -.
DR   Ensembl; ENSNBRT00000030358.1; ENSNBRP00000029599.1; ENSNBRG00000022522.1.
DR   GeneTree; ENSGT01070000253760; -.
DR   OMA; VMRNNQS; -.
DR   Proteomes; UP000261580; Unplaced.
DR   Bgee; ENSNBRG00000022522; Expressed in blood and 9 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   CDD; cd16040; SPRY_PRY_SNTX; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR018957; Znf_C3HC4_RING-type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00368; LRR_RI; 3.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50837; NACHT; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          73..100
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          198..332
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   DOMAIN          802..993
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
SQ   SEQUENCE   993 AA;  113343 MW;  E825E4665136AB7C CRC64;
     MICSSCNECV ENCFKEFHQR IYERLMGYDQ KCICVCRGQR SQSPTSSCVS VRSDWSKDRP
     PQFISVFKFS TSCGHWFCRQ CISSHWDQSA SSGDSSCPQC GKRSRTKPGL QEVLDEHKIS
     LRRRCERVTE GSDETGNRTL LNTIYTELYI TEGQSEEVHT QHEVRQLETA SKMDALHDAP
     ISCQDIFKAL PDQQRPIRVV LTNGVAGVGK TFSVQKFTLD WAEGLENQHV SVVVLLSFRE
     LNLIRDEQYS LLELLHVFHP TLQKVPAEKL AVSQLLFIFD GLDESRLSLD FTNRKLLSDV
     TQKSSVSQLL TNLIQGNLLP SALVWITSRP AAANQIPPTC VDRLTEVRGF TDAQKEEYFR
     RRFSDEELSS RIISHMKTSR SLHIMCRIPV FCWITATVLE HMLTTEQRGE LPKTLTDMYS
     HFLLVQTKRK KNKYHEGHET SPQKLTEVDR EKGNIMFYQE DLEQCGLDVT EASVYSGVCT
     EIFKRECVIF QKPVYCFVHL SIQEFLAAVY MFHCHTNKKT DVLKYFLGET WEDDHHNDYD
     YDLSSGQLDL FVRFLHGLCL ESNQTLLGSL LGQTENIPEN LQSVIDNLKW KNDNEISPDR
     SINIFHCLME MNELSVHQEI QEFLKSENRS EKLSEIHCSA LAYMLQMSEL VLDELDVQKY
     NTSYQGRLRL IPAVRNCRKA RLADCRLSET HCEVVVSALK SKSSHLTELD MSYNDLQDSG
     VKVLCTVLES PNCRLETLSL SACLITEEGC TSLAAALNSN PSHMRELDLS YNHPGDSGMK
     LLLAGQKDSH WRLDTLRYGD WTLSGMERMS DKGGNMLYSC QLTIDTNTVN TKLQLSDNNR
     KVTHVEEVQS YPDHPDRFDV RPQLLCSNSL TDRCYWEVEW RGEVEISVSY KGITRKGDGD
     DCWLGLNDQS WILYCSDRGP DSVWHNNKET TISSSSSSVS NRVGVYVDCP AGTLSFYRVS
     SDTLIHLHTF NTTFTQTLYP GFGFRSGSSV SLC
//